脂联素的救援：体外光诱导管理免疫检查点抑制剂诱导的毒性

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-04-11 DOI:10.1038/s41392-025-02205-y

Robin Reschke, Alexander H. Enk, Jessica C. Hassel

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引用次数: 0

摘要

在最近发表在《癌细胞》杂志上的一项研究中，Braun等人介绍了体外光合作用（ECP）作为一种新的免疫调节方法，可以减轻与免疫检查点抑制剂（ICIs）相关的免疫相关不良事件（irAEs），同时不影响抗肿瘤免疫ECP抑制Th1/Trm细胞活化和中性粒细胞浸润，同时通过脂联素增强抗炎巨噬细胞表型，促进类固醇难治性irAEs的消退。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

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Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

In a recent study published in Cancer Cell, Braun et al. introduced extracorporeal photopheresis (ECP) as a novel immunomodulatory approach to mitigate immune-related adverse events (irAEs) associated with immune checkpoint inhibitors (ICIs) without compromising anti-tumor immunity.¹ ECP suppressed Th1/Trm cell activation and neutrophil infiltration while enhancing an anti-inflammatory macrophage phenotype through adiponectin, facilitating the resolution of steroid-refractory irAEs.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.