{"title":"catp-4新等位基因的鉴定。","authors":"Anushree Gurjar, Amber R Krauchunas","doi":"10.17912/micropub.biology.001523","DOIUrl":null,"url":null,"abstract":"<p><p>CATP-4 is a subunit of a Na <sup>+</sup> /K <sup>+</sup> -ATPase important for sperm motility and fertility. Here, we report the characterization of a new allele of <i>catp-4</i> isolated from a forward genetic screen for sterile mutants. The <i>catp-4 ( as46 )</i> allele has a missense mutation that substitutes a highly conserved Glycine which lies close to an ATP binding site. This mutation results in a loss-of-function phenotype comparable to that of the <i>catp-4</i> null alleles, emphasizing the importance of this residue for CATP-4 function. This is for the first time that a phenotype has been reported for a single missense mutation in the <i>catp-4</i> gene.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976459/pdf/","citationCount":"0","resultStr":"{\"title\":\"Identification of a new allele of <i>catp-4</i>.\",\"authors\":\"Anushree Gurjar, Amber R Krauchunas\",\"doi\":\"10.17912/micropub.biology.001523\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>CATP-4 is a subunit of a Na <sup>+</sup> /K <sup>+</sup> -ATPase important for sperm motility and fertility. Here, we report the characterization of a new allele of <i>catp-4</i> isolated from a forward genetic screen for sterile mutants. The <i>catp-4 ( as46 )</i> allele has a missense mutation that substitutes a highly conserved Glycine which lies close to an ATP binding site. This mutation results in a loss-of-function phenotype comparable to that of the <i>catp-4</i> null alleles, emphasizing the importance of this residue for CATP-4 function. This is for the first time that a phenotype has been reported for a single missense mutation in the <i>catp-4</i> gene.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976459/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001523\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001523","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
CATP-4 is a subunit of a Na + /K + -ATPase important for sperm motility and fertility. Here, we report the characterization of a new allele of catp-4 isolated from a forward genetic screen for sterile mutants. The catp-4 ( as46 ) allele has a missense mutation that substitutes a highly conserved Glycine which lies close to an ATP binding site. This mutation results in a loss-of-function phenotype comparable to that of the catp-4 null alleles, emphasizing the importance of this residue for CATP-4 function. This is for the first time that a phenotype has been reported for a single missense mutation in the catp-4 gene.
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