[New opportunities for therapy of adjustment disorder in combat participants: results of a study on the domestic drug Aviandr].

Objective: To examine the clinical-psychopathological structure of adjustment disorders among sanitary losses of military personnel receiving medical care in a multidisciplinary military hospital, assessing the effectiveness of therapy for adjustment disorder symptoms with the drug Aviandr.

Material and methods: A single-center experimental uncontrolled study was conducted, involving 60 patients diagnosed with F43.2 - adjustment disorder; all patients were combat participants.

Results: The structure of adjustment disorders in the military personnel group was characterized by the predominance of an anxiety symptom complex; significant contributions to the disorder's structure also included depressive symptoms, dysphoria, and individual PTSD symptoms. Patients with spinal injuries and limb amputations experienced persistent pain syndrome resembling neuropathic and phantom pain. All patients received therapy with Aviandr at a dose of 10 mg twice daily for the first week, followed by an increase to 20 mg twice daily for the next three weeks. A statistically significant reduction in anxiety (p≤0.05) and post-traumatic stress symptoms was observed on the DTS, HARS, GAD-7, Likert scales scores and subjective assessments of state dynamics. In the group of patients with pain syndrome, the reduction in VAS scores was statistically significant but clinically insignificant.

Conclusion: The drug Aviandr demonstrated a significant clinical effect in this patient group with a high safety and tolerability profile, making it a potential option for the rapid and effective stabilization of the mental state of military personnel with acute stress-associated disorders.