The Development and Challenges of PET/MRI Dual-Modality Imaging Probes-An Update.

The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high-resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image-guided therapies. Central to the success of this dual-modality system is the development of specialized PET/MRI dual-modality probes, particularly those capable of simultaneous functionality, which present significant technical challenges in synthesis and applications. This review explores the advancements in PET/MRI probe development, summarizes the current applications, and highlights the critical challenges in translating PET/MRI probes from experimental research to clinical applications, offering insights into the future direction of this transformative imaging technology. EVIDENCE LEVEL: 5. TECHNICAL EFFICACY: Stage 1.