网格蛋白是修复DNA损伤所必需的。

IF 9.3 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Integrative Plant Biology Pub Date : 2025-04-04 DOI:10.1111/jipb.13910

Tongbin Yang, Xuerui Lu, Leilei Duan, Lili Wang, Shunping Yan

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引用次数: 0

摘要

拟南芥的基因筛选发现，同源重组（一种修复 DNA 双股断裂的精确机制）需要内吞作用的著名调节因子--凝集素。值得注意的是，CLATHRIN LIGHT CHAIN 2 定位于细胞核中，这表明凝集素在细胞核中具有非规范功能。

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Clathrin is required for DNA damage repair.

Genetic screening in Arabidopsis reveals that clathrin, a well-known regulator of endocytosis, is required for homologous recombination, a precise mechanism for repairing DNA double- strand breaks. Notably, CLATHRIN LIGHT CHAIN 2 localizes in the nucleus, suggesting that clathrin has non-canonical functions in the nucleus.

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来源期刊

Journal of Integrative Plant Biology 生物-生化与分子生物学

CiteScore

18.00

自引率

5.30%

发文量

220

审稿时长

3 months

期刊介绍： Journal of Integrative Plant Biology is a leading academic journal reporting on the latest discoveries in plant biology.Enjoy the latest news and developments in the field, understand new and improved methods and research tools, and explore basic biological questions through reproducible experimental design, using genetic, biochemical, cell and molecular biological methods, and statistical analyses.