抑郁症中凋亡相关的信号通路和治疗方法。

IF 3.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Neuroscience Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fnins.2025.1559597

Xuyang Feng, Wenyu Zhang, Xiaoxi Liu, Qiuxuan Wang, Xiao Dang, Jingxian Han, Xuezhu Zhang

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引用次数: 0

摘要

铁中毒是一种新发现的细胞死亡形式，其特点是铁过度积累和脂质过氧化。研究表明，铁变态反应与抑郁症之间存在密切联系；然而，确切的信号通路和潜在的分子机制仍不清楚。本综述总结了铁氧化在抑郁症中的作用及其相关信号通路。此外，还综述了基于铁氧化理论的抑郁症治疗方法，为预防和治疗抑郁症提供了新的靶点，并为今后研究铁氧化与抑郁症的关系奠定了基础。

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Ferroptosis-associated signaling pathways and therapeutic approaches in depression.

Ferroptosis, a newly identified form of cell death, is characterized by excessive iron accumulation and lipid peroxidation. Studies indicate a strong association between ferroptosis and depression; however, the precise signaling pathways and underlying molecular mechanisms remain unclear. This review summarizes the role of ferroptosis in depression and its associated signaling pathways. Additionally, therapeutic approaches for depression based on ferroptosis theory are reviewed, providing novel targets for the prevention and treatment of depression and laying a foundation for future research on the relationship between ferroptosis and depression.

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来源期刊

Frontiers in Neuroscience NEUROSCIENCES-

CiteScore

6.20

自引率

4.70%

发文量

2070

审稿时长

14 weeks

期刊介绍： Neural Technology is devoted to the convergence between neurobiology and quantum-, nano- and micro-sciences. In our vision, this interdisciplinary approach should go beyond the technological development of sophisticated methods and should contribute in generating a genuine change in our discipline.