碳水化合物合成正在进入数据驱动的数字时代。

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-04-03 DOI:10.1002/chem.202500289

Eric Thomas Sletten, Jakob B Wolf, José Danglad-Flores, Peter H Seeberger

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引用次数: 0

摘要

聚糖在生物过程中是至关重要的，但其非模板的异质结构使结构-功能分析复杂化。糖基化是合成糖化学中的关键反应，由于其复杂的机制和需要影响反应结果的保护基团，仍然无法完全预测。该概念强调了糖化学的最新进展，并强调了数字工具的集成，包括自动化，计算建模和数据管理，以改善碳水化合物合成并支持该领域的进一步发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Carbohydrate Synthesis is Entering the Data-Driven Digital Era.

Glycans are vital in biological processes, but their non-templated, heterogeneous structures complicate structure-function analyses. Glycosylation, the key reaction in synthetic glycochemistry, remains not entirely predictable due to its complex mechanism and the need for protecting groups that impact reaction outcomes. This Concept highlights recent advancements in glycochemistry and emphasizes the integration of digital tools, including automation, computational modelling, and data management, to improve carbohydrate synthesis and support further progress in the field.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.