一种新型磁异质结NiO@Fe3O4光催化剂在心血管类药物喹唑啉-4(1H)- 1合成中的应用

IF 2.2 4区 化学 Q2 Engineering
Zhaowei Li
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引用次数: 0

摘要

喹唑啉-4(1H)- 1衍生物具有抗高血压作用,在包括心血管疾病在内的各种治疗领域显示出潜力。因此,这些杂环化合物的合成是至关重要的。介绍了NiO@Fe3O4纳米光催化剂作为一种新型介质,在200w高压汞灯照射下,一锅法合成了取代喹唑啉-4(1H)- 1衍生物。该环境友好型纳米光催化剂以甘草叶提取物为原料进行生物合成,并通过XPS、VSM、FT-IR、XRD、FE-SEM、TEM、EDS等多种分析技术进行表征。TEM分析表明制备的NiO@Fe3的尺寸为20-45 nm。优化实验证明,在室温好氧条件下,以1 mmol 2-氨基苯甲酰胺和相应的芳香醛为缩合物,以30 mg NiO@Fe3O4纳米光催化剂存在,乙醇作为安全溶剂,照射20 min,可获得较高至优异的缩合反应收率。评价了光催化剂的稳定性和可重复使用性,证明了其实用性和可重复性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel magnetic heterojunction NiO@Fe3O4 photocatalyst in the synthesis of cardiovascular quinazolin-4(1H)-one drugs

Quinazolin-4(1H)-one derivatives have shown potential in various therapeutic areas, including cardiovascular diseases because of their antihypertensive effects. Therefore, synthesis of these heterocyclic compounds is of prime importance. The NiO@Fe3O4 nanophotocatalyst has been introduced as a novel mediator for the one-pot synthesis of some substituted quinazolin-4(1H)-one derivatives under illumination of a 200 W high-pressure mercury vapor lamp. The environmental-friendly nanophotocatalyst is biosynthesized using the extract of Glycyrrhiza glabra leaves and characterized through various analytical techniques such as XPS, VSM, FT-IR, XRD, FE-SEM, TEM, and EDS. The TEM analysis revealed the size of 20–45 nm for the prepared NiO@Fe3. Optimization experiments proved that the condensation reactions can be achieved under aerobic conditions at room temperature with high to excellent yields with 1 mmol of 2-aminobenzamide and the corresponding aromatic aldehyde in the presence of 30 mg of NiO@Fe3O4 nanophotocatalyst in ethanol as a safe solvent during 20 min under irradiation. The stability and reusability of the photocatalyst were assessed, demonstrating its practical applicability and reproducibility.

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来源期刊
Chemical Papers
Chemical Papers Chemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍: Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.
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