利用bn -联苯纳米片作为硫鸟嘌呤的潜在载体：一种有前途的药物递送系统

IF 2.2 4区化学 Q2 Engineering

Chemical Papers Pub Date : 2025-02-26 DOI:10.1007/s11696-025-03956-2

Yousef A. Bin Jardan, Yashwantsinh Jadeja, Soumya V. Menon, Debasish Shit, Girish Chandra Sharma, Mounir M. Bekhit, Rasha Ali Abdalhuseen, Salah Hassan Zain Al-Abdeen, Ruaa Sattar

{"title":"利用bn -联苯纳米片作为硫鸟嘌呤的潜在载体：一种有前途的药物递送系统","authors":"Yousef A. Bin Jardan, Yashwantsinh Jadeja, Soumya V. Menon, Debasish Shit, Girish Chandra Sharma, Mounir M. Bekhit, Rasha Ali Abdalhuseen, Salah Hassan Zain Al-Abdeen, Ruaa Sattar","doi":"10.1007/s11696-025-03956-2","DOIUrl":null,"url":null,"abstract":"<div><p>A substantial amount of research has been conducted on the development of innovative systems for drug delivery. This study explores the use of boron nitride biphenylene network (BPN–BN) as a BPN analog of biphenyl. DFT calculations were undertaken for examining the interactions between BPN–BN and thioguanine (THG), which is an anticancer drug. The THG/BPN–BN system was found to exhibit chemical reactivity, making it ideal for the bonding of THG with the adhesive site. Additionally, the non-covalent interaction analysis was conducted to understand the complexes of THG with BPN–BN, revealing that the interactions between THG and BPN–BN were strong. Consequently, it was confirmed that BPN–BN has the potential to serve as a potential nanocarrier for THG.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 4","pages":"2531 - 2540"},"PeriodicalIF":2.2000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Utilizing BN-biphenylene nanosheet as a potential carrier for thioguanine: a promising drug delivery system\",\"authors\":\"Yousef A. Bin Jardan, Yashwantsinh Jadeja, Soumya V. Menon, Debasish Shit, Girish Chandra Sharma, Mounir M. Bekhit, Rasha Ali Abdalhuseen, Salah Hassan Zain Al-Abdeen, Ruaa Sattar\",\"doi\":\"10.1007/s11696-025-03956-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A substantial amount of research has been conducted on the development of innovative systems for drug delivery. This study explores the use of boron nitride biphenylene network (BPN–BN) as a BPN analog of biphenyl. DFT calculations were undertaken for examining the interactions between BPN–BN and thioguanine (THG), which is an anticancer drug. The THG/BPN–BN system was found to exhibit chemical reactivity, making it ideal for the bonding of THG with the adhesive site. Additionally, the non-covalent interaction analysis was conducted to understand the complexes of THG with BPN–BN, revealing that the interactions between THG and BPN–BN were strong. Consequently, it was confirmed that BPN–BN has the potential to serve as a potential nanocarrier for THG.</p></div>\",\"PeriodicalId\":513,\"journal\":{\"name\":\"Chemical Papers\",\"volume\":\"79 4\",\"pages\":\"2531 - 2540\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-02-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Papers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11696-025-03956-2\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Papers","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11696-025-03956-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Engineering","Score":null,"Total":0}

引用次数: 0

摘要

在开发创新的给药系统方面已经进行了大量的研究。本研究探讨了使用氮化硼联苯网络（BPN - bn）作为联苯的BPN类似物。DFT计算用于检查BPN-BN与抗癌药物硫鸟嘌呤（THG）之间的相互作用。发现THG/ BPN-BN体系表现出化学反应性，使其成为THG与粘附位点结合的理想选择。此外，对THG与BPN-BN的配合物进行了非共价相互作用分析，发现THG与BPN-BN之间的相互作用很强。因此，BPN-BN具有作为THG的潜在纳米载体的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Utilizing BN-biphenylene nanosheet as a potential carrier for thioguanine: a promising drug delivery system

查看原文本刊更多论文

Utilizing BN-biphenylene nanosheet as a potential carrier for thioguanine: a promising drug delivery system

A substantial amount of research has been conducted on the development of innovative systems for drug delivery. This study explores the use of boron nitride biphenylene network (BPN–BN) as a BPN analog of biphenyl. DFT calculations were undertaken for examining the interactions between BPN–BN and thioguanine (THG), which is an anticancer drug. The THG/BPN–BN system was found to exhibit chemical reactivity, making it ideal for the bonding of THG with the adhesive site. Additionally, the non-covalent interaction analysis was conducted to understand the complexes of THG with BPN–BN, revealing that the interactions between THG and BPN–BN were strong. Consequently, it was confirmed that BPN–BN has the potential to serve as a potential nanocarrier for THG.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.