精确肽干扰物：肿瘤靶向治疗的新一代

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-04-01 DOI:10.1016/j.cellsig.2025.111783

Bria O'Gorman , Sean F. Cooke , Connor M. Blair

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引用次数: 0

摘要

在治疗上，针对癌症中病理重塑的蛋白质-蛋白质相互作用网络，使用肽干扰物越来越多地代表了治疗顽固性癌症的临床有吸引力的方法。在这篇综述中，我们在肿瘤特定背景下绘制临床前和临床阶段肽干扰物景观，并讨论对患者产生重大影响的关键临床实例；展示了肽干扰物作为下一代靶向治疗在精准医学中的关键作用。

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Precision peptide disruptors: The next generation of targeted therapeutics in oncology

Therapeutically targeting the pathologically remodelled protein-protein interaction network in cancer with peptide disruptors increasingly represents a clinically attractive approach to treating recalcitrant cancers. In this review, we map the pre-clinical and clinical-stage peptide disruptor landscape within an oncology-specific context and discuss key clinical examples that are making significant impact to patients; demonstrating a key role for peptide disruptors in precision medicine as a next-generation targeted therapeutic.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.