红景天苷通过抑制铁下垂减轻败血症引起的急性肾损伤。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-02 DOI:10.1080/10286020.2025.2481291

Ling-Ling Zhen, Ming-Tong Hou, Sheng-Bao Wang

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引用次数: 0

摘要

红景天苷是一种具有抗炎、抗氧化等多种药理活性的中药，而急性肾损伤（AKI）是一种常见的脓毒症引起的急性炎症反应。本研究利用转录组学和代谢组学相结合的方法，发现花生四烯酸代谢相关的铁下垂是红景天苷改善败血症诱导AKI （SI-AKI）的重要机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis.

Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.