Time-of-flight mass spectrometry with a pulsed glow discharge-A versatile tool in modern analytical chemistry: From elemental and isotopic analysis of solids to determination of VOCs and inorganic compounds in ambient air.

This article describes the key achievements over the past 10 years in the microsecond pulsed glow discharge mass spectrometry applied to the analysis of solids and gaseous mixtures. The solid-state analysis allows studying solid materials with different conductivities, including direct simultaneous quantitation of light elements with high ionization energy (N, O, F, Cl, etc.), heavy elements (U, Th, etc.), and isotope analysis. Dielectric materials analysis is considered in details with special emphasis on sample preparation approaches. Particular attention is focused on a new application of the technique for detection of volatile organic and inorganic compounds in gas mixtures (model gas mixtures, ambient air and exhaled air). This approach has prospects for solving medical and environmental problems as well as for process gas monitoring. Several applications (He determination in deuterium, detection of VOCs, Xe and other inorganic compounds in air) are presented as examples. Using the high resolution (6000 for Pb, m/z 208) of Lumas PGD-301 time-of-flight mass spectrometer helps to eliminate most of the interferences and thereby improves the analytical performance. Combination of high energy electron ionization with soft Penning and other ionization mechanisms allows to detect almost all known elements and molecules.