增生性糖尿病视网膜病变患者应激性高血糖率与新生血管性青光眼的关系。

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2025-04-01 DOI:10.1186/s12886-025-03982-4

Chuankai Fang, Di He, Minghai Shen, Runan Chen, Xiaomei Shen

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引用次数: 0

摘要

目的：探讨增殖性糖尿病视网膜病变（PDR）患者应激性高血糖比（SHR）与新生血管性青光眼（NVG）发生的关系。我们的目的是探索SHR作为NVG风险生物标志物的潜在作用，并确定这种关联的人口统计学和临床修饰因素。方法：我们使用我院2010年至2020年10年间的电子健康记录进行了回顾性队列研究。被诊断为PDR的患者被纳入研究，排除了那些没有糖尿病相关NVG或SHR数据不完整的患者。SHR采用入院血糖和HbA1c水平计算。采用Logistic回归和Cox比例风险模型评估SHR和NVG之间的相关性，并对潜在混杂因素进行调整。结果：共确认1245例患者，其中378例（30.3%）有PDR合并NVG。整个队列的平均SHR为2.9，PDR合并NVG组的平均SHR更高（3.2 vs. 2.7, p）。结论：我们的研究表明，SHR和NVG与PDR患者之间存在显著相关性，某些亚组表现出更强的相关性。这些研究结果表明，由SHR测量的血糖变异性可能在NVG的发展中发挥关键作用，可以为高危患者预防和管理NVG提供量身定制的临床策略。

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Association between stress hyperglycemia ratio and neovascular glaucoma in patients with proliferative diabetic retinopathy.

Objective: The purpose of this study was to investigate the association between the stress hyperglycemia ratio (SHR) and the occurrence of neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR). We aimed to explore the potential role of SHR as a biomarker for NVG risk and to identify demographic and clinical modifiers of this association.

Methods: We conducted a retrospective cohort study using electronic health records from our hospital over a 10-year period from 2010 to 2020. Patients diagnosed with PDR were included, with exclusions for those without diabetes-related NVG or incomplete SHR data. The SHR was calculated using admission blood glucose and HbA1c levels. Logistic regression and Cox proportional hazards modeling were used to assess the association between SHR and NVG, adjusting for potential confounders.

Results: A total of 1,245 patients were identified, of which 378 (30.3%) had PDR with NVG. The mean SHR for the entire cohort was 2.9, with a higher mean SHR observed in the PDR with NVG group (3.2 vs. 2.7, p < 0.001). Multivariate logistic regression analysis revealed a significant association between SHR and NVG (OR 2.5, 95% CI 1.9 to 3.3, p < 0.001). Subgroup analysis showed a stronger association between SHR and NVG risk in males (HR 1.4, 95% CI 1.1 to 1.7, p = 0.01) and patients over 65 years old (HR 1.5, 95% CI 1.2 to 1.9, p = 0.001). The association was also more pronounced in patients with a diabetes duration exceeding 15 years (HR 1.4, 95% CI 1.1 to 1.8, p = 0.01).

Conclusion: Our study demonstrated a significant association between SHR and NVG with PDR patients, with certain subgroups showing a stronger association. These findings suggest that glycemic variability, as measured by SHR, may play a critical role in the development of NVG and could inform tailored clinical strategies for the prevention and management of NVG in high-risk patients.

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.