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IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Pediatric Cardiology Pub Date : 2025-03-31 DOI:10.1007/s00246-025-03846-0

Obaid Ur Rehman, Eeshal Fatima, Adeena Jamil, Zain Ali Nadeem, Aimen Nadeem, Ahmed Kamal Siddiqi, Richard A Krasuski

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引用次数: 0

摘要

我们试图确定美国人口中与法洛氏四联症 (ToF) 相关的死亡率趋势，并特别强调与年龄、种族和地域相关的差异。我们从美国疾病预防控制中心 WONDER 数据库中检索了死亡证明数据，确定了每 100 万人口的粗死亡率 (CMR) 和年龄调整死亡率 (AAMR) 以及 95% CIs，并通过 Joinpoint 回归确定了年度百分比变化 (APC) 和平均年度百分比变化 (AAPC)。从 1999 年到 2020 年，共报告了 5523 例与 ToF 相关的死亡病例，其中近一半发生在婴儿出生后的第一年。从 1999 年到 2020 年，AAMR 稳步下降（AAPC：- 1.26，95% CI - 2.29 至 -0.38，P 值 = 0.012）。男性的 AAMR（0.91）略高于女性（0.77）。非西班牙裔（NH）黑人/非洲裔美国人的 AAMR（1.00）高于 NH 白人（0.83）。在所有年龄组中，一岁以下婴儿的 CMR 最高。尽管所有年龄层的发病率都较低，但从 2013 年到 2020 年，45 岁的发病率显著上升（APC 6.17，95% CI 0.79 至 20.35，P 值 = 0.047）。与城市地区相比，随着时间的推移，农村地区的急性心肌梗死死亡率一直较高，而下降幅度较小，大多数死亡发生在医疗机构。在过去 20 年中，美国与 ToF 相关的死亡率稳步下降。事实证明，将资源集中用于这些高风险人群可能是有益的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Trends in Tetralogy of Fallot-Related Mortality in the United States Between 1999 and 2020.

We sought to identify mortality trends related to Tetralogy of Fallot (ToF) in the U.S. population, with specific emphasis on age-related, racial, and geographic differences. Death certificate data was retrieved from the CDC WONDER database, where crude mortality rate (CMR) and age-adjusted mortality rates (AAMR) with 95% CIs per 1,000,000 population were identified, along with annual percentage changes (APCs) and average annual percentage change (AAPC) determined by Joinpoint regression. From 1999 to 2020, a total of 5523 deaths were reported in association with ToF, with nearly half of all deaths occurring during the first year of life. The AAMR steadily decreased from 1999 to 2020 (AAPC: - 1.26, 95% CI - 2.29 to -0.38, p-value = 0.012). Males had a slightly higher AAMR (0.91) than females (0.77). Non-Hispanic (NH) Blacks/African Americans had a higher AAMR (1.00) compared with NH Whites (0.83). Infants less than a year old exhibited the highest CMRs among all age groups. Although lower rates were seen among all age strata < 45 years of age, deaths in patients > 45 years significantly increased from 2013 to 2020 (APC 6.17, 95% CI 0.79 to 20.35, p-value = 0.047). Rural areas consistently exhibited greater AAMRs and lesser declines over time compared to urban areas, with most deaths occurring in medical facilities. Over the last 2 decades in the US, the mortality rates associated with ToF have steadily decreased. Focusing resources on these higher risk populations may prove beneficial.

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来源期刊

Pediatric Cardiology 医学-小儿科

CiteScore

3.30

自引率

6.20%

发文量

258

审稿时长

12 months

期刊介绍： The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.