前列腺癌的靶向和局部活检：第一个真实世界的数据。

IF 2.8 2区医学 Q2 UROLOGY & NEPHROLOGY

World Journal of Urology Pub Date : 2025-03-26 DOI:10.1007/s00345-025-05585-6

Thibaut Long-Depaquit, Renaud Corral, Alessandro Uleri, Arthur Peyrottes, Jennifer Campagna, Harry Toledano, Cyrille Bastide, Michael Baboudjian

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引用次数: 0

摘要

导读：mri靶向活检提高前列腺癌（PCa）的诊断，但系统远处活检增加过度诊断和过度治疗。局部活检可提高诊断效率。方法：这项前瞻性单中心研究纳入biopsy-naïve患者接受经会阴mri引导下的认知融合和区域取样活检。结果：50例患者中，66%有临床显著性PCa， 16%无显著性PCa， 18%无癌。非癌性病例无需再次活检。在12例接受保留神经的根治性前列腺切除术的患者中，25%的患者有双侧病变，有两个阳性边缘。结论：这种新的活检模板有助于减少不必要的采样和相关风险。需要更大规模的比较研究来证实这些发现。

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Targeted and regional biopsy in prostate cancer: first real-world data.

Introduction: MRI-targeted biopsies enhance prostate cancer (PCa) diagnostics, but systematic distant biopsies increase overdiagnosis and overtreatment. Regional biopsies may optimize diagnostic efficiency.

Methods: This prospective single-center study included biopsy-naïve patients undergoing transperineal MRI-guided biopsies with cognitive fusion and regional sampling.

Results: Among 50 patients, 66% had clinically significant PCa, 16% insignificant PCa, and 18% no cancer. No re-biopsies were needed for non-cancerous cases. Of 12 patients undergoing nerve-sparing radical prostatectomy, 25% had a bilateral disease, with two positive margins.

Conclusion: This novel biopsy template may help reduce unnecessary sampling and associated risks. Larger comparative studies are needed to confirm these findings.

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来源期刊

World Journal of Urology 医学-泌尿学与肾脏学

CiteScore

6.80

自引率

8.80%

发文量

317

审稿时长

4-8 weeks

期刊介绍： The WORLD JOURNAL OF UROLOGY conveys regularly the essential results of urological research and their practical and clinical relevance to a broad audience of urologists in research and clinical practice. In order to guarantee a balanced program, articles are published to reflect the developments in all fields of urology on an internationally advanced level. Each issue treats a main topic in review articles of invited international experts. Free papers are unrelated articles to the main topic.