含1,2-二胺基胸腺嘧啶类似物的双联物的合成及金属离子结合性能。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-03-27 DOI:10.1002/cbic.202500017

Takahiro Atsugi, Shoji Fujiwara, Jiro Kondo, Akira Ono

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引用次数: 0

摘要

合成了在3N位置具有1,2-二氨基侧链的胸腺嘧啶类似物，并将其转化为酰胺基，用于合成寡核苷酸。它用于制备含有1,2-二氨基侧链作为X残基的寡核苷酸。热变性研究进行了双相包含X-X对在存在和不存在金属离子。在本研究中使用的多种金属离子中，Cd（II）、Co（II）、Cu（II）、Ni（II）和Zn（II）离子增加了双相稳定性。结果证明了设计含多种金属离子的金属碱基对的新策略。

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Synthesis and Metal-Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2-Diamine Groups.

Thymidine analogue with a 1,2-diamino side chain at the 3N position is synthesized and converted into an amidite unit for oligonucleotide synthesis. It is used for preparing oligonucleotides containing a 1,2-diamino side chain as X residue. Thermal denaturation studies are performed on a duplex containing an X-X pair in the presence and absence of metal ions. Among various metal ions used in this research, Cd(II), Co(II), Cu(II), Ni(II), and Zn(II) ions increased the duplex stability. The results prove the new strategy to design metallo-base pairs containing various metal ions.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).