肿瘤诱导的中性粒细胞通过白细胞介素-17a分泌诱导结直肠癌上皮-间质转化和转移

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-03-28 DOI:10.1016/j.cyto.2025.156928

Yibing Gong , Qingshuang Luo , Haiqi Tan , Jingyi Long , Longtai Hu , Moyed abd alhussain Hamza Al-saadawe , Jinke Yao , Xiaoming Lyu , Lizhen Qiu , Gongfa Wu

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引用次数: 0

摘要

中性粒细胞在防御感染和调节免疫反应中的作用是众所周知的。在癌症中，肿瘤相关的中性粒细胞在肿瘤的进展中也起着重要的作用。然而，它们与人类结直肠肿瘤相互作用的具体机制尚未完全阐明。我们的研究发现，肿瘤诱导的中性粒细胞可以通过分泌IL-17a激活结直肠癌细胞中的STAT3信号通路。这导致结直肠癌细胞的迁移和侵袭增加，通过触发上皮-间质转化（EMT）促进肿瘤生长。这些发现表明，由肿瘤诱导的中性粒细胞分泌的IL-17a通过IL-17a/STAT3信号通路参与结直肠癌的发展。这为结直肠癌的潜在治疗提供了新的见解。

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Tumor-educated Neutrophils Induce Epithelial-mesenchymal Transition and Metastasis in Colorectal Cancer Through Interleukin-17a Secretion

The role of neutrophils in defending against infections and regulating immune responses is well-known. In cancer, tumor-associated neutrophils also play a significant role in the progression of tumors. However, the specific mechanisms of their interaction with human colorectal tumors have not been fully elucidated. Our study found that tumor-educated neutrophils can activate the STAT3 signaling pathway in colorectal cancer cells by secreting IL-17a. This leads to increased migration and invasion of colorectal cancer cells, promoting tumor growth by triggering epithelial-to-mesenchymal transition (EMT). These findings suggest that IL-17a secreted by tumor-educated neutrophils contributes to the development of colorectal cancer through the IL-17a/STAT3 signaling pathway. This provides new insights for potential treatments for colorectal cancer.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.