软骨钙素：其在软骨和骨中的调节和多功能的见解

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2025-03-24 DOI:10.1016/j.diff.2025.100861

Wensha Zhu , Zilong Zhao , Weigang Yuwen , Linlin Qu , Zhiguang Duan , Chenhui Zhu , Daidi Fan

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引用次数: 0

摘要

Ⅱ型胶原蛋白（COLⅡ）是软骨基质的主要成分，特别存在于玻璃体、软骨、骨和其他骨骼元素中。因此，COLⅡ的正常表达对于软骨的正常发育、线性生长、力学性能和自我修复能力至关重要。软骨钙素是Ⅱ型前胶原的c -前肽，不仅是COLⅡ合成的标志，也是软骨中最丰富的多肽之一。本研究探讨了软骨钙素在COLⅡ合成中的关键作用，全面探讨了其在软骨和骨相关疾病中的调节和多种功能。我们的研究结果表明，COL2A1的软骨钙素编码域的突变影响软骨和骨的临床发育。

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Chondrocalcin: Insights into its regulation and multi-function in cartilage and bone

Type Ⅱ collagen (COLⅡ) is the primary constituent of the cartilage matrix, specifically present in vitreous bodies, cartilage, bone, and other skeletal elements. Therefore, the normal expression of COLⅡ is crucial for the normal development, linear growth, mechanical properties, and self-repairing ability of cartilage. Chondrocalcin, the C-propeptide of type Ⅱ procollagen, is not only a marker of COLⅡ synthesis but also one of the most abundant polypeptides in cartilage. This work examines the pivotal role of chondrocalcin in the synthesis of COLⅡ, comprehensively examining its regulation and multi-functions in cartilage and bone related diseases. Our findings suggest that mutations in the chondrocalcin-encoding domain of COL2A1 affect cartilage and bone development in clinical conditions.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.