高致病性H5N1禽流感：历史、现状和前景。

IF 4 2区医学 Q2 VIROLOGY

Journal of Virology Pub Date : 2025-03-27 DOI:10.1128/jvi.02209-24

Florian Krammer, Enikö Hermann, Angela L Rasmussen

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引用次数: 0

摘要

H5N1禽流感大流行已导致鸟类和哺乳动物的跨物种传播，在野生动物、家禽和美国奶牛中引起暴发，具有一系列宿主依赖的致病结果。虽然没有观察到人际传播，但人畜共患病人间病例数量的增加为适应性突变或重新组合创造了机会。本宝典探讨了H5N1进化分支2.3.4.4b的历史、演变、病毒学和流行病学及其大流行潜力。迫切需要采取减少大流行风险的措施。

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Highly pathogenic avian influenza H5N1: history, current situation, and outlook.

The H5N1 avian panzootic has resulted in cross-species transmission to birds and mammals, causing outbreaks in wildlife, poultry, and US dairy cattle with a range of host-dependent pathogenic outcomes. Although no human-to-human transmission has been observed, the rising number of zoonotic human cases creates opportunities for adaptive mutation or reassortment. This Gem explores the history, evolution, virology, and epidemiology of clade 2.3.4.4b H5N1 relative to its pandemic potential. Pandemic risk reduction measures are urgently required.

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来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.