补充植物甾醇-豆甾醇对阿霉素诱导的心脏毒性的心脏保护作用。

IF 1.2 4区 医学 Q3 ANATOMY & MORPHOLOGY
Ying Wang
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引用次数: 0

摘要

背景与目的:豆甾醇是一种植物甾醇,广泛存在于包括大豆和其他豆类在内的各种植物来源中,由于其药理特性而发挥着重要的药理作用。研究表明,豆甾醇具有抗炎、抗氧化和降低胆固醇的作用,使其成为治疗心血管疾病的有希望的候选者。在这项工作中,我们阐明了豆甾醇对阿霉素引起的大鼠心脏毒性的保护作用。材料和方法:因此,我们评估了补充豆甾醇预防阿霉素引起的心脏毒性的效力。雄性Wistar大鼠用阿霉素(2.5 mg/kg)治疗,外加25和50 mg/kg剂量的豆甾醇治疗14 d。治疗第14天进行尾袖容积描记术评估血流动力学参数。采用商业试剂盒检测实验大鼠氧化应激标志物、心功能标志物、心肌损伤标志物和炎症生物标志物的浓度。对心脏组织进行组织病理学分析。并与NF-κB进行对接研究。结果:豆甾醇能有效增加阿霉素诱导大鼠的体重和心脏重量,提高血流动力学参数。豆甾醇处理还通过增加抗氧化剂来降低阿霉素诱导大鼠的氧化应激,降低心功能指标,降低心肌损伤指标。此外,豆甾醇治疗还降低了阿霉素诱导大鼠的炎症标志物。组织病理学分析和对接分析结果进一步支持了豆甾醇对NF-κB的良好结合亲和力。结论:尾袖容积描记和心脏组织病理分析结果真实地证实了豆甾醇对阿霉素诱导的心脏毒性的抑制作用。结论补充植物化学成分豆甾醇有说服力地改善了阿霉素诱导的心脏毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardioprotective effect of phytosterol stigmasterol supplementation against doxorubicin-induced cardiotoxicity.

Background and objectives: Stigmasterol, a phytosterol abundantly found in various plant sources, including soybeans and other legumes, plays a significant pharmaceutical role due to its pharmacological properties. Research suggests that stigmasterol exhibits anti-inflammatory, antioxidant, and cholesterol-lowering effects, making it a promising candidate for managing cardiovascular disorders. In this work, we elucidated the cardioprotective potency of stigmasterol against doxorubicin-induced cardiotoxicity in rats.

Materials and methods: Hence we have evaluated the potency of stigmasterol supplementation in preventing doxorubicin-induced cardiotoxicity. Male Wistar rats were treated with doxorubicin (2.5 mg/kg) and supplemented with 25 and 50 mg/kg doses of stigmasterol for 14 days. On 14th day of treatment tail-cuff plethysmography was conducted to assess the hemodynamic parameters. The concentrations of oxidative stress markers, cardiac function markers, myocardial damage markers, and inflammatory biomarkers were assessed in the experimental rats using the commercial kits. The heart tissues were subjected to the histopathological analysis. Docking study was also conducted with NF-κB.

Results: The stigmasterol treatment effectively increased the body weight and heart weight and elevated the hemodynamic parameters in doxorubinin-induced rats. The stigmasterol treatment also decreased the oxidative stress via increasing antioxidants, reduced the cardiac function markers, and decreased the myocardial damage markers in the doxorubicin-induced rats. Furthermore, the stigmasterol treatment also reduced the inflammatory markers in the doxorubicin-induced rats. The cardioprotective properties of the stigmasterol was further supported by the results of histopathological analysis and docking analysis where it showed excellent binding affinity for NF-κB.

Conclusions: The results of tail-cuff plethysmography and cardiac tissue histopathological analysis authentically proved the inhibitory effect of stigmasterol against doxorubicin induced cardiotoxicity. To conclude supplementation with phytochemical stigmasterol persuasively ameliorated doxorubicin induced cardiotoxicity.

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来源期刊
Folia morphologica
Folia morphologica ANATOMY & MORPHOLOGY-
CiteScore
2.40
自引率
0.00%
发文量
218
审稿时长
6-12 weeks
期刊介绍: "Folia Morphologica" is an official journal of the Polish Anatomical Society (a Constituent Member of European Federation for Experimental Morphology - EFEM). It contains original articles and reviews on morphology in the broadest sense (descriptive, experimental, and methodological). Papers dealing with practical application of morphological research to clinical problems may also be considered. Full-length papers as well as short research notes can be submitted. Descriptive papers dealing with non-mammals, cannot be accepted for publication with some exception.
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