派姆单抗诱导抗- yo抗体阳性小脑炎1例报告。

IF 0.8 Q4 RESPIRATORY SYSTEM
Respirology Case Reports Pub Date : 2025-03-24 eCollection Date: 2025-03-01 DOI:10.1002/rcr2.70160
Takafumi Yamano, Toshihide Yokoyama, Tadashi Ishida
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引用次数: 0

摘要

我们报告一例罕见的派姆单抗诱导的IV期肺腺癌患者的抗yo抗体阳性小脑炎。经过两个周期的联合治疗,患者出现眼球震颤和共济失调。尽管肿瘤消退和正常的磁共振成像(MRI)结果,脑脊液分析显示淋巴细胞为主的高细胞性,增加的蛋白质和寡克隆带。免疫检查点抑制剂(ICI)相关的小脑炎是在排除了传染性原因、转移和癌性脑膜炎并伴有抗yo抗体阳性后诊断出来的。甲强的松龙脉冲无效,但大剂量静脉注射免疫球蛋白治疗缓解症状。据我们所知,这是首例肺腺癌中伴有抗yo抗体的ici相关性小脑炎病例报告。本病例强调了副肿瘤抗体检测在诊断ici相关脑炎中的重要性,特别是在MRI表现正常的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pembrolizumab-Induced Anti-Yo-Antibody-Positive Cerebellitis: A Case Report.

We report a rare case of pembrolizumab-induced anti-Yo-antibody-positive cerebellitis in a patient with stage IV lung adenocarcinoma. Following two cycles of combination therapy, the patient developed nystagmus and ataxia. Despite tumour regression and normal magnetic resonance imaging (MRI) findings, cerebrospinal fluid analysis revealed lymphocyte-dominant hypercellularity, increased protein, and oligoclonal bands. Immune checkpoint inhibitor (ICI)-related cerebellitis was diagnosed after excluding infectious causes, metastases, and cancerous meningitis coupled with a positive anti-Yo antibody. Methylprednisolone pulse was ineffective, but high-dose intravenous immunoglobulin therapy resolved symptoms. To the best of our knowledge, this is the first case report of ICI-related cerebellitis with anti-Yo-antibody in lung adenocarcinoma. This case highlights the importance of paraneoplastic antibody testing in diagnosing ICI-related encephalitis, especially in cases of normal MRI findings.

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来源期刊
Respirology Case Reports
Respirology Case Reports RESPIRATORY SYSTEM-
CiteScore
1.40
自引率
0.00%
发文量
178
审稿时长
8 weeks
期刊介绍: Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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