低流量：在资源有限的情况下选择有限的流式细胞仪面板。

IF 5.7 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2025-03-17 DOI:10.1016/j.blre.2025.101284

Ailie Ross , Donna Rudd , Joel Wight

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引用次数: 0

摘要

血液系统恶性肿瘤（HM）患者的诊断和治疗受到资源有限的环境（RLS）获得病理服务的阻碍。国际公认的HM指南和诊断标准要求使用复杂的分析，包括全面的流式细胞术（FCM），以进行最低限度的基本诊断和治疗，这在RLS中具有技术挑战性。这篇综述将定义这些缺点，并检查有限的FCM面板在RLS中的使用。虽然存在有限慢性淋巴细胞白血病（CLL） FCM小组的共识指南，但这尚未在大型队列中得到验证。目前，在资源有限的情况下，没有基于共识和资源分层的诊断方案来定义有限的FCM小组，以诊断急性白血病。对于诊断最常见的HM，这种有证据支持的指南的需求尚未得到满足。本系统综述从文献中定义了可能在此期间使用的基于共识的有限FCM小组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Low flow: Selecting a limited flow cytometry panel where resources are constrained

Diagnosis and treatment of patients with haematological malignancies (HM) is hampered by access to pathology services in resource-limited settings (RLS). Internationally accepted guidelines and diagnostic criteria for HM require access to sophisticated analysis including comprehensive flow cytometry (FCM) for minimum essential diagnosis and treatment, which is technically challenging in RLS. This review will define these shortcomings and examine the use of limited FCM panels in RLS.

While a consensus guideline exists for a limited chronic lymphocytic leukaemia (CLL) FCM panel, this has yet to be validated in a large cohort. Currently, there are no consensus-based and resource-stratified diagnostic protocols defining limited FCM panels for the diagnosis of acute leukaemia where resources are limited.

There is an unmet need for such guidelines, supported by evidence, for the diagnosis of the most common HM. This systematic review defines consensus-based limited FCM panels from the literature that may be used in the interim.

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来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.