Note on ethene and other low-molecular weight hydrocarbons in environmental tobacco smoke.

Levels of ethene and propene, together with those of some other light hydrocarbons (propane, butane, isobutane and ethyne), have been measured under realistic conditions in environmental tobacco smoke (ETS) as a step towards the elucidation of the sources of 2-hydroxyethyl and 2-hydroxypropyl adducts of hemoglobin observed in non-smokers. These adducts may reflect in vivo doses of carcinogenic epoxides that are metabolites of the respective alkenes. The data show that 2.0 mg ethene, 1.4 mg propene, and 0.7 mg propane together with smaller amounts of butane, isobutane and ethyne are released per cigarette smoked (0.66 g tobacco) of a common Swedish brand. The alkenes in ETS should be considered as contributing factors to a risk of systemic cancer from passive smoking. With regard to alkene intake, even a relatively mild exposure to ETS (2 cigarettes per h for 5 h per day in a 33 m3 room with one air change per hour is estimated to correspond to the active smoking of about one cigarette per day.