Yumeng Li, Ran Chen, Juanjuan Lv, Jiali Su, Mengxu Gao, Kaifu Ma, Xiupei Cheng, Wei Shu
{"title":"一种高选择性、高灵敏度的用于HSO3-生物系统成像和食品安全监测的双功能荧光探针。","authors":"Yumeng Li, Ran Chen, Juanjuan Lv, Jiali Su, Mengxu Gao, Kaifu Ma, Xiupei Cheng, Wei Shu","doi":"10.1007/s00216-025-05837-9","DOIUrl":null,"url":null,"abstract":"<div><p>In the food field, HSO<sub>3</sub><sup>-</sup> is commonly used as a beverage additive, antioxidant, enzyme inhibitor, and preservative to extend shelf life and freshness. However, excessive intake of exogenous HSO<sub>3</sub><sup>-</sup> can lead to abnormal HSO<sub>3</sub><sup>-</sup> concentration levels in the body, causing cardiovascular and respiratory diseases. This highlights the urgent need to develop a rapid and sensitive probe for the quantitative detection of HSO<sub>3</sub><sup>-</sup> in foods and biosystems. In this study, we design and synthesize a novel HSO<sub>3</sub><sup>-</sup> fluorescent probe named <b>DCPD</b>. Bioimaging experiments show that <b>DCPD</b> has good mitochondrial targeting and can be used to imaging the redox process of HSO<sub>3</sub><sup>-</sup>/H<sub>2</sub>O<sub>2</sub> in cells and tissue. In addition, <b>DCPD</b> has been used in detecting HSO<sub>3</sub><sup>-</sup> in foods with satisfactory recoveries (98.62–105.06%), further demonstrating its compatibility and utility. Thus, the <b>DCPD</b> probe offers substantial promise for application in food analysis and the assessment of HSO<sub>3</sub><sup>-</sup> concentrations in biological systems.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":"417 13","pages":"2947 - 2956"},"PeriodicalIF":3.8000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A dual-functional fluorescent probe for biosystem imaging and food safety monitoring of HSO3- with high selectivity and sensitivity\",\"authors\":\"Yumeng Li, Ran Chen, Juanjuan Lv, Jiali Su, Mengxu Gao, Kaifu Ma, Xiupei Cheng, Wei Shu\",\"doi\":\"10.1007/s00216-025-05837-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the food field, HSO<sub>3</sub><sup>-</sup> is commonly used as a beverage additive, antioxidant, enzyme inhibitor, and preservative to extend shelf life and freshness. However, excessive intake of exogenous HSO<sub>3</sub><sup>-</sup> can lead to abnormal HSO<sub>3</sub><sup>-</sup> concentration levels in the body, causing cardiovascular and respiratory diseases. This highlights the urgent need to develop a rapid and sensitive probe for the quantitative detection of HSO<sub>3</sub><sup>-</sup> in foods and biosystems. In this study, we design and synthesize a novel HSO<sub>3</sub><sup>-</sup> fluorescent probe named <b>DCPD</b>. Bioimaging experiments show that <b>DCPD</b> has good mitochondrial targeting and can be used to imaging the redox process of HSO<sub>3</sub><sup>-</sup>/H<sub>2</sub>O<sub>2</sub> in cells and tissue. In addition, <b>DCPD</b> has been used in detecting HSO<sub>3</sub><sup>-</sup> in foods with satisfactory recoveries (98.62–105.06%), further demonstrating its compatibility and utility. Thus, the <b>DCPD</b> probe offers substantial promise for application in food analysis and the assessment of HSO<sub>3</sub><sup>-</sup> concentrations in biological systems.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":462,\"journal\":{\"name\":\"Analytical and Bioanalytical Chemistry\",\"volume\":\"417 13\",\"pages\":\"2947 - 2956\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-03-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical and Bioanalytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00216-025-05837-9\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00216-025-05837-9","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
A dual-functional fluorescent probe for biosystem imaging and food safety monitoring of HSO3- with high selectivity and sensitivity
In the food field, HSO3- is commonly used as a beverage additive, antioxidant, enzyme inhibitor, and preservative to extend shelf life and freshness. However, excessive intake of exogenous HSO3- can lead to abnormal HSO3- concentration levels in the body, causing cardiovascular and respiratory diseases. This highlights the urgent need to develop a rapid and sensitive probe for the quantitative detection of HSO3- in foods and biosystems. In this study, we design and synthesize a novel HSO3- fluorescent probe named DCPD. Bioimaging experiments show that DCPD has good mitochondrial targeting and can be used to imaging the redox process of HSO3-/H2O2 in cells and tissue. In addition, DCPD has been used in detecting HSO3- in foods with satisfactory recoveries (98.62–105.06%), further demonstrating its compatibility and utility. Thus, the DCPD probe offers substantial promise for application in food analysis and the assessment of HSO3- concentrations in biological systems.
期刊介绍：
Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
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