Efficacy of platelet-rich plasma in facial rejuvenation: A systematic review.

Aim: To evaluate the effects of Platelet-Rich Plasma (PRP) in facial rejuvenation.

Methods: A systematic review was conducted from November 2022 to September 2024. Literature searches were performed in the databases PubMed, CINAHL, SCOPUS, Cuiden and Scielo using the terms platelet rich plasma, rejuvenation, skin, plasma skin regeneration, and platelet rich plasma rejuvenation. Studies published with participants over 18 years old, using exclusively PRP for facial rejuvenation, were selected. Reviews and meta-analyses, as well as studies involving patients with conditions that could affect the treatment, were excluded.

Results: Nine clinical trials and two observational study were included. Clinically, four studies indicated that PRP improved wrinkles and skin texture. Histologically, this substance induced a cascade of growth factors that increased dermal density, reducing wrinkles and improving skin luminosity and hydration. Despite these observations, discrepancies were observed regarding the different application techniques (topical or injected) and doses administered. Adverse effects were rare, including bruising and edema caused by injections and occasionally, papules, scaling, and dryness at the injection site.

Conclusion: Platelet-rich plasma may be effective for facial rejuvenation based on histological results and patient references. However, further studies are needed to determine the most the most appropriate procedure for its administration.

Prospero register number: CRD42024513433.