揭示泛凋亡在肝脏疾病中的作用：机制与治疗意义》。

IF 6 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver International Pub Date : 2025-03-21 DOI:10.1111/liv.70000

Wanyuan Xiong, Junfeng Li, Aiping Tian, Xiaorong Mao

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引用次数: 0

摘要

泛凋亡是细胞死亡的一种多模式形式，涉及炎症、凋亡和坏死途径，在肝脏疾病的发展中起着关键作用。本文首先概述了泛凋亡的定义和特点，然后探讨了泛凋亡在不同类型肝病中的作用机制，包括急性肝损伤、肝衰竭、代谢功能障碍相关性脂肪肝和肝细胞癌。此外，本文还分析了 PANoptosis 的分子调控网络和潜在的治疗靶点。最后，本文总结了目前有关肝脏疾病中 PAN 细胞凋亡的研究以及未来的研究方向，并综述了 PAN 细胞凋亡这一新兴细胞死亡机制在肝脏疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Unravelling the Role of PANoptosis in Liver Diseases: Mechanisms and Therapeutic Implications

查看原文本刊更多论文

Unravelling the Role of PANoptosis in Liver Diseases: Mechanisms and Therapeutic Implications

PANoptosis is a multimodal form of cell death that involves inflammatory, apoptotic, and necroptotic pathways, playing a key role in the development of liver diseases. This article first outlines the definition and characteristics of PANoptosis, and then explores its mechanisms of action in different types of liver diseases, including acute liver injury, liver failure, metabolic dysfunction-associated fatty liver disease, and hepatocellular carcinoma. Furthermore, this article analyses the molecular regulatory network of PANoptosis and potential therapeutic targets. Finally, this article summarises the current research on PANoptosis in liver diseases and future research directions, and it reviews the role of the emerging cell death mechanism of PANoptosis in liver diseases.

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来源期刊

Liver International 医学-胃肠肝病学

CiteScore

13.90

自引率

4.50%

发文量

348

审稿时长

2 months

期刊介绍： Liver International promotes all aspects of the science of hepatology from basic research to applied clinical studies. Providing an international forum for the publication of high-quality original research in hepatology, it is an essential resource for everyone working on normal and abnormal structure and function in the liver and its constituent cells, including clinicians and basic scientists involved in the multi-disciplinary field of hepatology. The journal welcomes articles from all fields of hepatology, which may be published as original articles, brief definitive reports, reviews, mini-reviews, images in hepatology and letters to the Editor.