关于各认知阶段血浆标志物及其与轻度脑外伤病史关系的初步研究。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-03-21 DOI:10.1177/13872877251325757

Christian LoBue, Barbara E Stopschinski, Nil Saez Calveras, Amber Salter, Doug Galasko, Chris Giza, C Munro Cullum, Peter M Douglas, John Hart

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引用次数: 0

摘要

在衰老过程中轻度创伤性脑损伤（mTBI）史的潜在影响尚未得到充分研究。在有正常认知、轻度认知障碍（MCI）和阿尔茨海默氏型痴呆（DAT），有或没有mTBI病史的匹配参与者中，测量了7种血浆标志物。磷酸化的tau181在患有MCI和DAT的mTBI +个体中显示出中等效应值，并且在mTBI + DAT个体中观察到低淀粉样蛋白-β 42/40和高神经丝光的效应值。该初步报告显示血浆来源标记物在检测mTBI病史与阿尔茨海默病及相关疾病发展之间的关联方面具有潜在作用。

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A preliminary study on plasma markers across cognitive stages and links to a history of mild traumatic brain injury.

Potential implications of a history of mild traumatic brain injury (mTBI) during aging are understudied. Seven plasma markers were measured in matched participants having normal cognition, mild cognitive impairment (MCI) and dementia of the Alzheimer's type (DAT) with and without a history of mTBI. Phosphorylated tau₁₈₁ showed a moderate effect size for being greater in mTBI + individuals having MCI and DAT, and effect sizes for lower amyloid-β 42/40 and higher neurofilament light were seen for mTBI + DAT individuals. This preliminary report shows a potential role of plasma-derived markers in detecting associations between mTBI history and the development of Alzheimer's disease and related disorders.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.