促动素-2和降钙素原对危重患者脓毒症的诊断准确性：一项前瞻性观察研究。

IF 1.5 Q3 CRITICAL CARE MEDICINE

Indian Journal of Critical Care Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI:10.5005/jp-journals-10071-24930

Kavyashree Bhat, Nikhil Kothari, Ankur Sharma, Shilpa Goyal, Tanvi Meshram, Bharat Paliwal, Pradeep Bhatia, Shrimanjunath Sankanagoudar

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引用次数: 0

摘要

目的：脓毒症是全球ICU死亡率的一个重要因素。因此，早期诊断和适当治疗对于降低死亡率至关重要。我们计划本研究探讨prokinetic -2 （PK-2）在脓毒症患者中的诊断意义。材料和方法：我们的重症监护病房（ICU）收治的成年脓毒症患者纳入了这项前瞻性观察性研究。于入院当天及ICU住院第7天分别检测降钙素原（PCT）、PK-2水平。观察患者死亡率28 d。结果：本研究纳入83例符合纳入标准的患者。Prokineticin-2对脓毒症的诊断敏感性为70.6%，优于PCT的64.7%。在预测死亡率方面，PCT的敏感性为95.5%，而Prokineticin-2的敏感性更高，为98.4%。结论：Prokinectin-2可用于ICU成年脓毒症患者的筛查。如何引用本文：Bhat K， Kothari N, Sharma A, Goyal S, Meshram T, Paliwal B，等。促动素-2和降钙素原对危重患者脓毒症的诊断准确性：一项前瞻性观察研究。中华检验医学杂志；2015;29(3):268-272。

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Prokineticin-2 and Procalcitonin's Diagnostic Accuracy for Sepsis in Critically Ill Patients: A Prospective Observational Study.

Objective: Sepsis stands as a significant contributor to mortality in ICU settings worldwide. Early diagnosis and appropriate treatment are therefore essential to reduce mortality. We planned this study to investigate the diagnostic significance of prokineticin-2 (PK-2) in patients with sepsis.

Materials and methods: Adult patients with sepsis who were admitted to our intensive care unit (ICU) were included in this prospective observational study. On the day of admission and the 7th day of the ICU stay, the levels of procalcitonin (PCT) and PK-2 were assessed. Patients' mortality was observed for 28 days.

Results: This research involved 83 patients meeting the inclusion criteria. Prokineticin-2 showed a diagnostic sensitivity of 70.6% for sepsis, outperforming PCT with a sensitivity of 64.7%. In predicting mortality, PCT displayed a sensitivity of 95.5%, whereas Prokineticin-2 demonstrated an even higher sensitivity at 98.4%.

Conclusion: Prokinectin-2 can be used for screening adult patients with sepsis admitted to ICU.

How to cite this article: Bhat K, Kothari N, Sharma A, Goyal S, Meshram T, Paliwal B, et al. Prokineticin-2 and Procalcitonin's Diagnostic Accuracy for Sepsis In Critically Ill Patients: A Prospective Observational Study. Indian J Crit Care Med 2025;29(3):268-272.

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来源期刊

Indian Journal of Critical Care Medicine CRITICAL CARE MEDICINE-

CiteScore

3.50

自引率

10.00%

发文量

299

期刊介绍： Indian Journal of Critical Care Medicine (ISSN 0972-5229) is specialty periodical published under the auspices of Indian Society of Critical Care Medicine. Journal encourages research, education and dissemination of knowledge in the fields of critical and emergency medicine.