细胞外囊泡在癌症的通讯:我们可以读取的信息和如何回答

IF 27.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alena Semeradtova, Michaela Liegertova, Regina Herma, Magdalena Capkova, Chiara Brignole, Genny Del Zotto
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引用次数: 0

摘要

细胞外囊泡(EVs)正在成为肿瘤微环境(TME)中细胞间通讯的重要介质,深刻影响癌症的进展。这些纳米大小的囊泡由肿瘤细胞和基质细胞释放,携带多种蛋白质、核酸和脂质,反映了动态的细胞景观,并介导细胞之间复杂的相互作用。本文综述了ev在肿瘤中的生物发生、组成和功能作用,强调了其在基础研究和临床应用中的重要意义。我们讨论了癌细胞如何操纵EV生物发生途径,产生富含促肿瘤分子的囊泡,探索EV对癌症关键特征的具体贡献,如血管生成、转移和免疫逃避,强调它们在形成TME和驱动治疗耐药性中的作用。同时,我们提交了关于电动汽车货物如何作为微创液体活检生物标志物的宝贵来源及其治疗潜力的最新知识,特别是作为靶向药物递送载体和免疫调节剂,展示了它们在提高癌症治疗的有效性和安全性方面的前景。通过破译ev携带的复杂信息,我们可以更深入地了解癌症生物学,并制定更有效的早期检测、靶向治疗和免疫治疗策略,为个性化和精确的癌症医学的新时代铺平道路,并有可能显著改善患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extracellular vesicles in cancer´s communication: messages we can read and how to answer
Extracellular vesicles (EVs) are emerging as critical mediators of intercellular communication in the tumor microenvironment (TME), profoundly influencing cancer progression. These nano-sized vesicles, released by both tumor and stromal cells, carry a diverse cargo of proteins, nucleic acids, and lipids, reflecting the dynamic cellular landscape and mediating intricate interactions between cells. This review provides a comprehensive overview of the biogenesis, composition, and functional roles of EVs in cancer, highlighting their significance in both basic research and clinical applications. We discuss how cancer cells manipulate EV biogenesis pathways to produce vesicles enriched with pro-tumorigenic molecules, explore the specific contributions of EVs to key hallmarks of cancer, such as angiogenesis, metastasis, and immune evasion, emphasizing their role in shaping TME and driving therapeutic resistance. Concurrently, we submit recent knowledge on how the cargo of EVs can serve as a valuable source of biomarkers for minimally invasive liquid biopsies, and its therapeutic potential, particularly as targeted drug delivery vehicles and immunomodulatory agents, showcasing their promise for enhancing the efficacy and safety of cancer treatments. By deciphering the intricate messages carried by EVs, we can gain a deeper understanding of cancer biology and develop more effective strategies for early detection, targeted therapy, and immunotherapy, paving the way for a new era of personalized and precise cancer medicine with the potential to significantly improve patient outcomes.
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来源期刊
Molecular Cancer
Molecular Cancer 医学-生化与分子生物学
CiteScore
54.90
自引率
2.70%
发文量
224
审稿时长
2 months
期刊介绍: Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.
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