综合激素避孕药（chc）对青春期女孩骨骼健康影响的系统综述

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of pediatric and adolescent gynecology Pub Date : 2025-03-15 DOI:10.1016/j.jpag.2025.03.004

Leek Mei Lim, Wogud Ben Said, Pallavi Latthe

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引用次数: 0

摘要

目的：总结复方激素避孕药（CHC）对青春期少女骨骼健康的影响。设计：使用以下数据库进行系统检索：Medline、EMBASE、CINAHL和Cochrane图书馆临床试验注册数据库，检索时间从成立到2024年7月。入选条件：纳入评估CHC对10-19岁少女骨骼健康影响的干预和队列研究。数据综合：纳入4项随机对照试验和8项观察性研究（n =2689）。结论：目前的证据表明，与未使用CHC的少女相比，使用CHC可减少骨累积。对骨累积的负面影响可能与CHC制剂中的雌激素剂量、使用的方案和使用时间有关。普洛斯彼罗注册号：普洛斯彼罗CRD 42024574905，于2024年7月31日。

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EFFECTS OF COMBINED HORMONAL CONTRACEPTIVES (CHC) ON BONE HEALTH IN ADOLESCENT GIRLS - A SYSTEMATIC REVIEW.

Objectives: To summarize the effects of combined hormonal contraceptives (CHC) on bone health in adolescent girls.

Design: A systematic search was performed using the following databases: Medline, EMBASE, CINAHL and Cochrane Library clinical trials register, from inception to July 2024.

Eligibility: Intervention and cohort studies that assessed the use of CHC on bone health in adolescent girls aged 10-19years old were included.

Data synthesis: Four randomized control trials and eight observational studies (n =2689) were included.

Conclusion: Current evidence indicates that the use of CHC in post-menarchal adolescent girls reduce bone accrual compared to non-users. The negative impact on bone accrual is likely related to the estrogen dose in the CHC preparation, the regimen used and the duration of use.

Prospero registration number: PROSPERO CRD 42024574905 on 31 July 2024.

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来源期刊

Journal of pediatric and adolescent gynecology 医学-妇产科学

CiteScore

3.90

自引率

11.10%

发文量

251

审稿时长

57 days

期刊介绍： Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology. The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.