Xiaolin Wang, Haohua Huang, Lichang Chen, Simin Guo, Qi-Ming Gong
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Babesiosis is a tick-transmitted illness caused by intraerythrocytic protozoa of the genus babesia. The severity of babesiosis ranges from asymptomatic infection to fatal disease. Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common interrelated inflammatory disorders that almost occur in people aged over 50 years. This report presents the first case of concurrent babesiosis and GCA/PMR in an old person.
Case Presentation
A 63-year-old man was admitted to the hospital with a 1-month history of fevers, accompanied by headache, muscle pain and fatigue. Laboratory tests revealed hemolytic anemia, with elevated C-reactive protein, serum IL-6 and erythrocyte sedimentation rate. FDG positron-emission tomography-computed tomography (PET-CT) scan exhibited increased uptake in aortic wall, multiple medium-to-large arteries and soft tissues. A blood smear revealed Babesia microti intracellular ring forms. Babesia microti infection was further confirmed by polymerase chain reaction (PCR) test. This patient was diagnosed as concurrent babesiosis and GCA/PMR. He was treated with glucocorticoid and antimicrobial therapy.
Conclusions
Concurrent babesiosis and GCA/PMR is rare. Further studies are needed to understand the mechanism of interaction between babesiosis and human immune system.
期刊介绍：
Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including:
• cellular and molecular immunology
• clinical immunology
• allergy
• immunochemistry
• immunogenetics
• immune signalling
• immune development
• imaging
• mathematical modelling
• autoimmunity
• transplantation immunology
• cancer immunology
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