新型氯沙坦有机锡配合物的合成及其生物活性

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2025-03-18 DOI:10.1134/S1990750824601334

T. A. Antonenko, O. A. Raykova, Yu. A. Gracheva, D. M. Mazur, V. A. Roznyatovsky, R. I. oglu Musaev, N. A. Gurova, M. S. Pshenichnikova, D. S. Yakovlev, E. R. Milaeva, A. A. Spasov

{"title":"新型氯沙坦有机锡配合物的合成及其生物活性","authors":"T. A. Antonenko, O. A. Raykova, Yu. A. Gracheva, D. M. Mazur, V. A. Roznyatovsky, R. I. oglu Musaev, N. A. Gurova, M. S. Pshenichnikova, D. S. Yakovlev, E. R. Milaeva, A. A. Spasov","doi":"10.1134/S1990750824601334","DOIUrl":null,"url":null,"abstract":"Novel organotin(IV) complexes based on losartan have been synthesized and characterized by 1H, 13C, 119Sn NMR, IR, ESI-MS and elemental analysis. The antiproliferative activity of the complexes was assessed in vitro against human cancer cells, while their cytotoxic effects were examined on primary rat skin fibroblasts. The compounds exhibited strong activity, significantly inducing apoptosis. Additionally, they effectively suppressed the spasmogenic effect induced by angiotensin II in isolated rat portal veins.","PeriodicalId":485,"journal":{"name":"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry","volume":"18 1 supplement","pages":"S6 - S17"},"PeriodicalIF":0.6000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel Organotin Complexes with Losartan: Synthesis and Biological Activity\",\"authors\":\"T. A. Antonenko, O. A. Raykova, Yu. A. Gracheva, D. M. Mazur, V. A. Roznyatovsky, R. I. oglu Musaev, N. A. Gurova, M. S. Pshenichnikova, D. S. Yakovlev, E. R. Milaeva, A. A. Spasov\",\"doi\":\"10.1134/S1990750824601334\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Novel organotin(IV) complexes based on losartan have been synthesized and characterized by 1H, 13C, 119Sn NMR, IR, ESI-MS and elemental analysis. The antiproliferative activity of the complexes was assessed in vitro against human cancer cells, while their cytotoxic effects were examined on primary rat skin fibroblasts. The compounds exhibited strong activity, significantly inducing apoptosis. Additionally, they effectively suppressed the spasmogenic effect induced by angiotensin II in isolated rat portal veins.\",\"PeriodicalId\":485,\"journal\":{\"name\":\"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry\",\"volume\":\"18 1 supplement\",\"pages\":\"S6 - S17\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry\",\"FirstCategoryId\":\"2\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1990750824601334\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry","FirstCategoryId":"2","ListUrlMain":"https://link.springer.com/article/10.1134/S1990750824601334","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

合成了新型氯沙坦有机锡配合物，并用1H、13C、119Sn NMR、IR、ESI-MS和元素分析对其进行了表征。体外研究了该复合物对人癌细胞的抗增殖活性，并对原代大鼠皮肤成纤维细胞进行了细胞毒性试验。化合物表现出较强的诱导凋亡活性。此外，它们还能有效抑制血管紧张素II对离体大鼠门静脉的致痉挛作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Novel Organotin Complexes with Losartan: Synthesis and Biological Activity

查看原文本刊更多论文

Novel Organotin Complexes with Losartan: Synthesis and Biological Activity

Novel organotin(IV) complexes based on losartan have been synthesized and characterized by ¹H, ¹³C, ¹¹⁹Sn NMR, IR, ESI-MS and elemental analysis. The antiproliferative activity of the complexes was assessed in vitro against human cancer cells, while their cytotoxic effects were examined on primary rat skin fibroblasts. The compounds exhibited strong activity, significantly inducing apoptosis. Additionally, they effectively suppressed the spasmogenic effect induced by angiotensin II in isolated rat portal veins.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.