HCC的新标准：tace -免疫联合治疗的高风险

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-03-14 DOI:10.1016/j.medj.2025.100635

Antonio D'Alessio, Lorenza Rimassa

引用次数: 0

摘要

经动脉化疗栓塞（TACE）长期以来一直是中期肝细胞癌（HCC）的标准治疗方法，但最近的两项3期试验重新定义了治疗模式。EMERALD-11和LEAP-0122试验分别显示TACE联合杜伐单抗/贝伐单抗或派姆单抗/lenvatinib显著改善无进展生存，但对患者选择和这些新组合的毒性仍然存在疑问。

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A new standard for HCC: The high stakes of TACE-immunotherapy combinations.

Transarterial chemoembolization (TACE) has long been the standard for intermediate-stage hepatocellular carcinoma (HCC), but two recent phase 3 trials have redefined treatment paradigms. The EMERALD-1¹ and LEAP-012² trials demonstrated significant progression-free survival improvement with TACE combined with durvalumab/bevacizumab or pembrolizumab/lenvatinib, respectively, but doubts remain regarding the patient selection and the toxicity of these novel combinations.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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