{"title":"Magnetic resonance imaging indices for early Alzheimer's disease detection: Brain clearance markers.","authors":"Moto Nakaya, Koji Kamagata, Kaito Takabayashi, Christina Andica, Wataru Uchida, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Osamu Abe, Shigeki Aoki","doi":"10.1177/0271678X251321305","DOIUrl":null,"url":null,"abstract":"<p><p>The Alzheimer's disease (AD) continuum is characterized by amyloid and tau protein deposition, which is partly attributable to the dysfunction of the brain clearance system. However, the specific phase in the AD continuum wherein aberrant clearance is present remains unclear. This study aimed to assess noninvasive magnetic resonance imaging (MRI) indices related to brain clearance functions, such as choroid plexus volume (CPV), lateral ventricular volume (LVV), and the index of diffusivity along the perivascular space (ALPS index), across the Alzheimer's disease (AD) spectrum. The CPV, LVV, and ALPS index in amyloid beta (Aβ)-negative healthy controls (HCs) and Aβ-positive HCs as well as in patients with Aβ-negative subjective cognitive decline (SCD), with Aβ-positive SCD, with mild cognitive impairment, and with AD were evaluated. The CPV and LVV were higher, whereas the ALPS index was lower in the patients with more severe disease. The ALPS index was significantly lower in Aβ-positive HCs than in Aβ-negative HCs. In SCD patients and those in the AD continuum, the MRI-based clearance markers were correlated with P-tau and T-tau protein levels and cognitive scores. In summary, brain clearance markers on MRI are associated with tau deposition, neurodegeneration and cognitive dysfunction.</p>","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X251321305"},"PeriodicalIF":4.9000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907505/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cerebral Blood Flow and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/0271678X251321305","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
阿尔茨海默病(AD)的特征是淀粉样蛋白和 tau 蛋白沉积,其部分原因是大脑清除系统功能失调。然而,目前仍不清楚在 AD 的连续过程中哪一阶段会出现异常清除。本研究旨在评估阿尔茨海默病(AD)谱系中与大脑清除功能相关的无创磁共振成像(MRI)指数,如脉络丛容积(CPV)、侧脑室容积(LVV)和沿血管周围空间扩散指数(ALPS指数)。研究人员评估了淀粉样β(Aβ)阴性健康对照组(HCs)、Aβ阳性健康对照组(HCs)以及Aβ阴性主观认知能力下降(SCD)患者、Aβ阳性SCD患者、轻度认知障碍患者和阿尔茨海默病患者的CPV、LVV和ALPS指数。在病情较重的患者中,CPV 和 LV 均较高,而 ALPS 指数较低。Aβ 阳性 HC 的 ALPS 指数明显低于 Aβ 阴性 HC。在 SCD 患者和 AD 连续体患者中,基于 MRI 的清除标记物与 P-tau 和 T-tau 蛋白水平及认知评分相关。总之,MRI 上的脑清除标记物与 tau 沉积、神经变性和认知功能障碍有关。
Magnetic resonance imaging indices for early Alzheimer's disease detection: Brain clearance markers.
The Alzheimer's disease (AD) continuum is characterized by amyloid and tau protein deposition, which is partly attributable to the dysfunction of the brain clearance system. However, the specific phase in the AD continuum wherein aberrant clearance is present remains unclear. This study aimed to assess noninvasive magnetic resonance imaging (MRI) indices related to brain clearance functions, such as choroid plexus volume (CPV), lateral ventricular volume (LVV), and the index of diffusivity along the perivascular space (ALPS index), across the Alzheimer's disease (AD) spectrum. The CPV, LVV, and ALPS index in amyloid beta (Aβ)-negative healthy controls (HCs) and Aβ-positive HCs as well as in patients with Aβ-negative subjective cognitive decline (SCD), with Aβ-positive SCD, with mild cognitive impairment, and with AD were evaluated. The CPV and LVV were higher, whereas the ALPS index was lower in the patients with more severe disease. The ALPS index was significantly lower in Aβ-positive HCs than in Aβ-negative HCs. In SCD patients and those in the AD continuum, the MRI-based clearance markers were correlated with P-tau and T-tau protein levels and cognitive scores. In summary, brain clearance markers on MRI are associated with tau deposition, neurodegeneration and cognitive dysfunction.
期刊介绍:
JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.