评估乳糜泻患儿在采用无麸质饮食后最初 15 个月的粘膜恢复情况。

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-03-14 DOI:10.14309/ajg.0000000000003400

Denis Chang, Madison Wong, Cleo R Davidowitz, Imad Absah, Vahe Badalyan, Mohammad K Chaaban, Lisa Fahey, Daniela M Isaac, Maya Khanna, Marihan Lansing, Edwin Liu, Catherine Raber, Arunjot Singh, Marisa G Stahl, Catharine M Walsh, Jocelyn A Silvester, Maureen M Leonard

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ASSESSING MUCOSAL RECOVERY DURING THE FIRST 15 MONTHS OF ADOPTING A GLUTEN-FREE DIET IN CHILDREN WITH CELIAC DISEASE.

Objective: Determine contemporary rates of early mucosal recovery in children with celiac disease (CeD).

Methods: Multicenter retrospective cohort study in Canada and the United States. Children diagnosed with CeD between 2016 and 2021 who underwent a follow-up biopsy within 15 months of diagnosis were included.

Results: Overall, 96/130 (74%) had mucosal recovery, including 48% (12/25) children who were assessed within 3 months. Musculoskeletal symptoms at diagnosis were the only clinical characteristic associated with persistent enteropathy.

Conclusions: While mucosal recovery can occur within months, more than a quarter of children with CeD had persistent enteropathy within 15 months of treatment.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.