松菇的抗乳腺癌作用及其化学成分表征

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-03-11 DOI:10.1016/j.fitote.2025.106480

Jiajia Hu , Jiyuan Cao , Huixin Cheng , Xiaojin Liu , Guoying Zhang , Jianya Ling

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引用次数: 0

摘要

pini Phellinus pini （P. pini）作为一种传统的药用大型真菌在中国和东亚各国得到了广泛的应用。现代药理研究表明，pini在抗肿瘤治疗中具有重要的应用价值。然而，其主要抗乳腺癌活性物质和作用机制尚不清楚。在本研究中，我们发现Phellinus pini （PPE）甲醇提取物可以显著抑制4 T1细胞的活力，诱导凋亡，降低线粒体膜电位和4 T1细胞的S期阻滞。PPE可以恢复乳腺癌引起的肠道菌群失衡，调节氨基酸等内源性代谢物的含量。hplc -MS/MS分析表明，多酚类物质是其主要化学成分。这些结果为未来用pini蛋白治疗乳腺癌提供了实验支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Anti-breast cancer effect of Phellinus pini and its chemical composition characterization

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Anti-breast cancer effect of Phellinus pini and its chemical composition characterization

Phellinus pini (P. pini) has been widely utilized as a traditional medicinal macrofungus in China and various East Asian countries. Modern pharmacological studies have shown that P. pini has important application value in anti-tumor therapy. However, its main anti-breast cancer active substances and mechanism are still unclear. In this study, we demonstrated that the methanol extract of Phellinus pini (PPE) could significantly inhibit the viability of 4 T1 cells, induce apoptosis, decrease mitochondrial membrane potential and S phase arrest of 4 T1 cells. PPE can restore the imbalance of intestinal flora caused by breast cancer and regulate the content of endogenous metabolites such as amino acids. Q Exactive UPLC-MS/MS analysis showed that polyphenols are the main chemical components that exert the efficacy. These results provide experimental support for the potential future treatment of breast cancer with P. pini.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.