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IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-03-09 DOI:10.1016/j.phymed.2025.156610

Yinfeng Wu , Nan Jia , Jingyu Sun , Wei Liao , Jingxiang Xu , Weichao Chen , Chao Zhao

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引用次数: 0

摘要

背景从藻类中提取的多糖具有一系列生物学和健康益处。目的阐明海藻多糖与肿瘤免疫微环境之间微妙的相互作用，进一步了解海藻多糖的药用潜力。研究设计总结海藻多糖的来源、生物活性和肿瘤免疫微环境的特点，分析海藻多糖对肿瘤周围免疫环境的改变及其作为化疗药物免疫调节剂的潜力。方法使用选定的关键词在流行的学术搜索引擎上搜索2024年9月之前的文章，使用选定的关键词Google Scholar、PubMed、ScienceDirect、Scopus、Web of Science、Springer和官方网站。结果海藻多糖可以通过改变免疫细胞的工作方式和以不同方式影响炎症来对抗肿瘤。此外，海藻多糖还有望减轻化疗等传统癌症治疗方法的不良反应。结论随着研究不断揭示海藻多糖抗肿瘤作用的内在机制，海藻多糖有望成为开发新型癌症治疗方法的重要组成部分，为患者带来新的希望，并推动肿瘤学领域的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The roles of algal polysaccharides in modulating tumor immune microenvironment

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The roles of algal polysaccharides in modulating tumor immune microenvironment

Background

Polysaccharides from algae provide a range of biology and health benefits. Lately, there has been a significant interest in how algal polysaccharides affect the immune microenvironment around tumors.

Purpose

To elucidate the subtle interactions between algal polysaccharides and the tumor immune microenvironment to further understand the medicinal potential of algal polysaccharides.

Study design

To give a summary of the sources, bioactivities and characteristics of the tumor immune microenvironment of algal polysaccharides, and to analyze alteration of the immunological milieu surrounding tumors by algal polysaccharides and their potential as immunomodulators of chemotherapeutic agents.

Methods

Search popular academic search engines using selected keywords for articles ending before September 2024 using selected keywords Google Scholar, PubMed, ScienceDirect, Scopus, Web of Science, Springer, and official websites.

Results

Algal polysaccharides can fight tumors by changing how immune cells work and affecting inflammation in different ways. Moreover, algal polysaccharides have shown promise in mitigating the adverse effects associated with conventional cancer treatments, such as chemotherapy. Algal polysaccharides, through their immunomodulatory effects, can alleviate some of these side effects, leading to an enhanced overall treatment outcome.

Conclusion

As research continues to uncover the underlying mechanisms of their antitumor effects, algal polysaccharides are poised to become a vital component in the development of novel cancer treatments, providing new hope for patients and advancing the field of oncology.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.