靶向RNA聚合酶I治疗尤文氏肉瘤

IF 5.7 2区医学 Q1 Medicine

Cancer Science Pub Date : 2025-03-12 DOI:10.1111/cas.70047

Alexis Bruce, Gavin Anchondo, Rebekah Carter, Sergio Guerrero Pacheco, Hema Sri Kambala, Elizabeth Cortez, Kyra Parker, Le Su

引用次数: 0

摘要

药物抑制RNA聚合酶I活性是治疗尤文氏肉瘤的新途径。这是首次将核糖体生物发生途径的关键组分与尤文氏肉瘤生物学联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Targeting RNA Polymerase I in Ewing Sarcoma Treatment.

Pharmacologic inhibition of RNA polymerase I activity represents a new therapeutic approach for Ewing sarcoma. This is the first time key components of the ribosome biogenesis pathway have been linked to Ewing sarcoma biology.

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.