不宁腿综合征：神经化学和治疗。

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Seminars in Neurology Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI:10.1055/a-2538-3300

David Anguizola, Alba Garcia Aragón, Brian Moncada, Diego Garcia-Borreguero

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引用次数: 0

摘要

不宁腿综合征（RLS）是一种复杂的感觉运动障碍，其特征是关键神经化学通路的紊乱，包括多巴胺能、谷氨酸能和腺苷能系统。本文综述了目前关于RLS的研究进展，包括其临床特征和诊断、病理生理和治疗（非药物和药物）。我们研究了RLS与神经系统疾病、遗传易感性和脑铁缺乏之间的关系。针对谷氨酸和腺苷受体的新疗法，以及已建立的多巴胺激动剂和α2δ配体，为治疗提供了有希望的途径。

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Restless Legs Syndrome: Neurochemistry and Therapy.

Restless legs syndrome (RLS) is a complex sensorimotor disorder characterized by disturbances in key neurochemical pathways, including dopaminergic, glutamatergic, and adenosinergic systems. This review provides an overview of the current knowledge on RLS, including its clinical features and diagnosis, pathophysiology, and treatment (non-pharmacological and pharmacological). We examine the association between RLS and neurological disorders, genetic predispositions, and brain iron deficiency. Emerging therapies targeting glutamate and adenosine receptors, alongside established dopamine agonists and α2δ ligands, offer promising avenues for treatment.

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来源期刊

Seminars in Neurology 医学-临床神经学

CiteScore

4.60

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Neurology is a review journal on current trends in the evaluation, diagnosis, and treatment of neurological diseases. Areas of coverage include multiple sclerosis, central nervous system infections, muscular dystrophy, neuro-immunology, spinal disorders, strokes, epilepsy, motor neuron diseases, movement disorders, higher cortical function, neuro-genetics and neuro-ophthamology. Each issue is presented under the direction of an expert guest editor, and invited contributors focus on a single, high-interest clinical topic. Up-to-the-minute coverage of the latest information in the field makes this journal an invaluable resource for neurologists and residents.