香芹酚在哮喘治疗中的应用:对其治疗潜力和作用机制的全面综述。

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Deepa Neopane, Poonam Kushwaha
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引用次数: 0

摘要

哮喘是一种气道慢性炎症性疾病,仍然是一个重大的全球健康问题。目前的治疗侧重于症状管理和炎症控制,但寻找更有效和更安全的治疗方法仍在继续。香芹酚是一种天然存在的单萜酚,存在于各种植物的精油中,已成为一种有前景的生物活性化合物,具有有效的抗炎、抗氧化和支气管扩张特性。这篇综述探讨了香芹酚作为一种新型哮喘治疗药物的潜力。我们讨论了它的作用机制,包括炎症途径的调节,氧化应激的抑制,支气管肌肉的松弛。此外,还分析了临床前和临床研究评价卡维罗治疗哮喘的有效性和安全性。将carvacrol整合到现有的治疗方案中可以为哮喘管理提供多方面的方法,增强治疗效果并改善患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action.

Asthma, a chronic inflammatory disorder of the airways, remains a significant global health concern. Current treatments focus on symptom management and inflammation control, but the search for more effective and safer therapies continues. Carvacrol, a naturally occurring monoterpenoid phenol found in essential oils of various plants, has emerged as a promising bioactive compound with potent anti-inflammatory, antioxidant, and bronchodilatory properties. This review explores the potential of carvacrol as a novel therapeutic agent for asthma management. We discuss its mechanisms of action, including modulation of inflammatory pathways, inhibition of oxidative stress, and relaxation of bronchial muscles. Additionally, preclinical and clinical studies evaluating the efficacy and safety of carvacrol in asthma treatment are analyzed. The integration of carvacrol into existing treatment regimens could offer a multifaceted approach to asthma management, enhancing therapeutic outcomes and improving patients' quality of life.

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来源期刊
Pharmacological Reports
Pharmacological Reports 医学-药学
CiteScore
8.40
自引率
0.00%
发文量
91
审稿时长
6 months
期刊介绍: Pharmacological Reports publishes articles concerning all aspects of pharmacology, dealing with the action of drugs at a cellular and molecular level, and papers on the relationship between molecular structure and biological activity as well as reports on compounds with well-defined chemical structures. Pharmacological Reports is an open forum to disseminate recent developments in: pharmacology, behavioural brain research, evidence-based complementary biochemical pharmacology, medicinal chemistry and biochemistry, drug discovery, neuro-psychopharmacology and biological psychiatry, neuroscience and neuropharmacology, cellular and molecular neuroscience, molecular biology, cell biology, toxicology. Studies of plant extracts are not suitable for Pharmacological Reports.
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