{"title":"黄酮类化合物作为治疗和预防COVID-19的补充药物：第一部分：实验和临床应用","authors":"Ya. F. Zverev, A. Ya. Rykunova","doi":"10.1134/S0003683824700194","DOIUrl":null,"url":null,"abstract":"<p> The first part of this review is devoted to an analysis of the beneficial effect of flavonoids on the prevention, course, and outcomes of COVID-19. In addition to the well-known antioxidant, anti-inflammatory, immunomodulatory, antithrombotic, and antitumor effects, flavonoids, secondary metabolites of many plants, exhibit antiviral activity and low cytotoxicity. The basic stages of SARS-CoV-2 replication and COVID-19 pathogenesis are considered to identify possible targets for flavonoids. The effect of these polyphenolic compounds on SARS-CoV-2 both in in vitro systems and in animal models that adequately reproduce COVID-19 symptoms have been analyzed. The results of the first clinical trials on the prevention of this disease and the feasibility of using flavonoids, mainly quercetin, as adjuvant therapy are discussed.</p>","PeriodicalId":466,"journal":{"name":"Applied Biochemistry and Microbiology","volume":"60 8","pages":"1584 - 1602"},"PeriodicalIF":1.0000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flavonoids as Complementary Medicines for Therapy and Prevention of COVID-19: Part I. Experimental and Clinical Applications\",\"authors\":\"Ya. F. Zverev, A. Ya. Rykunova\",\"doi\":\"10.1134/S0003683824700194\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p> The first part of this review is devoted to an analysis of the beneficial effect of flavonoids on the prevention, course, and outcomes of COVID-19. In addition to the well-known antioxidant, anti-inflammatory, immunomodulatory, antithrombotic, and antitumor effects, flavonoids, secondary metabolites of many plants, exhibit antiviral activity and low cytotoxicity. The basic stages of SARS-CoV-2 replication and COVID-19 pathogenesis are considered to identify possible targets for flavonoids. The effect of these polyphenolic compounds on SARS-CoV-2 both in in vitro systems and in animal models that adequately reproduce COVID-19 symptoms have been analyzed. The results of the first clinical trials on the prevention of this disease and the feasibility of using flavonoids, mainly quercetin, as adjuvant therapy are discussed.</p>\",\"PeriodicalId\":466,\"journal\":{\"name\":\"Applied Biochemistry and Microbiology\",\"volume\":\"60 8\",\"pages\":\"1584 - 1602\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Biochemistry and Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0003683824700194\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Biochemistry and Microbiology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0003683824700194","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Flavonoids as Complementary Medicines for Therapy and Prevention of COVID-19: Part I. Experimental and Clinical Applications
The first part of this review is devoted to an analysis of the beneficial effect of flavonoids on the prevention, course, and outcomes of COVID-19. In addition to the well-known antioxidant, anti-inflammatory, immunomodulatory, antithrombotic, and antitumor effects, flavonoids, secondary metabolites of many plants, exhibit antiviral activity and low cytotoxicity. The basic stages of SARS-CoV-2 replication and COVID-19 pathogenesis are considered to identify possible targets for flavonoids. The effect of these polyphenolic compounds on SARS-CoV-2 both in in vitro systems and in animal models that adequately reproduce COVID-19 symptoms have been analyzed. The results of the first clinical trials on the prevention of this disease and the feasibility of using flavonoids, mainly quercetin, as adjuvant therapy are discussed.
期刊介绍：
Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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