呋喃-2-酮和铬-4-硫酮杂化体系的合成、晶体结构及抗菌活性评价

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2025-02-01 DOI:10.1080/10426507.2025.2461042

Ekaterina Mikhailovna Arzyamova , Alevtina Yur’evna Yegorova

{"title":"呋喃-2-酮和铬-4-硫酮杂化体系的合成、晶体结构及抗菌活性评价","authors":"Ekaterina Mikhailovna Arzyamova , Alevtina Yur’evna Yegorova","doi":"10.1080/10426507.2025.2461042","DOIUrl":null,"url":null,"abstract":"<div><div>A series of new hybrid systems containing furan-2-one and chromen-4-thione fragments were synthesized for the first time and characterized by elemental analysis, IR, NMR (1H,13C, NOESY) spectroscopy and X-ray structural analysis. It was shown that (E)-5-aryl-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-ones exist only in the E-configuration. Their in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was studied in liquid nutrient media by the serial dilution method. The results showed that (E)-5-(4-chlorophenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one and (E)-5-(4-methoxyphenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one demonstrated the best in vitro antibacterial properties against the bacterial culture Escherichia coli.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 2","pages":"Pages 164-173"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, crystal structure and evaluation of antibacterial activity of new hybrid systems containing furan-2-one and chromen-4-thione fragments\",\"authors\":\"Ekaterina Mikhailovna Arzyamova , Alevtina Yur’evna Yegorova\",\"doi\":\"10.1080/10426507.2025.2461042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A series of new hybrid systems containing furan-2-one and chromen-4-thione fragments were synthesized for the first time and characterized by elemental analysis, IR, NMR (1H,13C, NOESY) spectroscopy and X-ray structural analysis. It was shown that (E)-5-aryl-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-ones exist only in the E-configuration. Their in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was studied in liquid nutrient media by the serial dilution method. The results showed that (E)-5-(4-chlorophenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one and (E)-5-(4-methoxyphenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one demonstrated the best in vitro antibacterial properties against the bacterial culture Escherichia coli.</div></div>\",\"PeriodicalId\":20056,\"journal\":{\"name\":\"Phosphorus, Sulfur, and Silicon and the Related Elements\",\"volume\":\"200 2\",\"pages\":\"Pages 164-173\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phosphorus, Sulfur, and Silicon and the Related Elements\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1042650725000103\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phosphorus, Sulfur, and Silicon and the Related Elements","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1042650725000103","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

摘要

首次合成了一系列含有呋喃-2-酮和铬-4-硫酮片段的杂化体系，并用元素分析、IR、NMR （1H、13C、noesi）光谱和x射线结构分析对其进行了表征。结果表明，(E)-5-芳基-3-[（4-硫氧基- 4h -铬-3-基）亚甲基]呋喃-2(3H)- 1只存在于E构型中。采用连续稀释法研究其对大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌的体外抗菌活性。结果表明，(E)-5-（4-氯苯基）-3-[（4-硫氧基- 4h -铬-3-基）亚甲基]呋喃-2(3H)- 1和(E)-5-（4-甲氧基苯基）-3-[（4-硫氧基- 4h -铬-3-基）亚甲基]呋喃-2(3H)- 1对细菌培养的大肠杆菌具有最佳的体外抗菌性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis, crystal structure and evaluation of antibacterial activity of new hybrid systems containing furan-2-one and chromen-4-thione fragments

查看原文本刊更多论文

Synthesis, crystal structure and evaluation of antibacterial activity of new hybrid systems containing furan-2-one and chromen-4-thione fragments

A series of new hybrid systems containing furan-2-one and chromen-4-thione fragments were synthesized for the first time and characterized by elemental analysis, IR, NMR (¹H,¹³C, NOESY) spectroscopy and X-ray structural analysis. It was shown that (E)-5-aryl-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-ones exist only in the E-configuration. Their in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was studied in liquid nutrient media by the serial dilution method. The results showed that (E)-5-(4-chlorophenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one and (E)-5-(4-methoxyphenyl)-3-[(4-thioxo-4H-chromen-3-yl)methylene]furan-2(3H)-one demonstrated the best in vitro antibacterial properties against the bacterial culture Escherichia coli.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.