{"title":"基因毒性化合物检测的信号分析:在化疗癌症患者和处理细胞毒性药物的护士尿液中的应用。","authors":"S Burgaz, Y N Ozdamar, A E Karakaya","doi":"10.1177/096032718800700607","DOIUrl":null,"url":null,"abstract":"<p><p>1. The excretion of thioethers was determined in the urine of nurses handling cytotoxic drugs (n = 10) and cancer patients under chemotherapy (n = 32). 2. An occupational non-exposed group served as control (n = 28). 3. We found no association between the handling of cytotoxic drugs and occupational exposure of nurses. Cancer patients under chemotherapy showed abnormally high values of thioethers, while urinary thioether concentration was, consistently, rather low in some individuals under intensive chemotherapy. 4. We conclude that periodical urinary thioether determinations should be made available to hospital staff as well as cancer patients to minimize the risks of the cytotoxic drugs.</p>","PeriodicalId":13194,"journal":{"name":"Human toxicology","volume":"7 6","pages":"557-60"},"PeriodicalIF":0.0000,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/096032718800700607","citationCount":"24","resultStr":"{\"title\":\"A signal assay for the detection of genotoxic compounds: application on the urines of cancer patients on chemotherapy and of nurses handling cytotoxic drugs.\",\"authors\":\"S Burgaz, Y N Ozdamar, A E Karakaya\",\"doi\":\"10.1177/096032718800700607\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>1. The excretion of thioethers was determined in the urine of nurses handling cytotoxic drugs (n = 10) and cancer patients under chemotherapy (n = 32). 2. An occupational non-exposed group served as control (n = 28). 3. We found no association between the handling of cytotoxic drugs and occupational exposure of nurses. Cancer patients under chemotherapy showed abnormally high values of thioethers, while urinary thioether concentration was, consistently, rather low in some individuals under intensive chemotherapy. 4. We conclude that periodical urinary thioether determinations should be made available to hospital staff as well as cancer patients to minimize the risks of the cytotoxic drugs.</p>\",\"PeriodicalId\":13194,\"journal\":{\"name\":\"Human toxicology\",\"volume\":\"7 6\",\"pages\":\"557-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/096032718800700607\",\"citationCount\":\"24\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/096032718800700607\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/096032718800700607","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A signal assay for the detection of genotoxic compounds: application on the urines of cancer patients on chemotherapy and of nurses handling cytotoxic drugs.
1. The excretion of thioethers was determined in the urine of nurses handling cytotoxic drugs (n = 10) and cancer patients under chemotherapy (n = 32). 2. An occupational non-exposed group served as control (n = 28). 3. We found no association between the handling of cytotoxic drugs and occupational exposure of nurses. Cancer patients under chemotherapy showed abnormally high values of thioethers, while urinary thioether concentration was, consistently, rather low in some individuals under intensive chemotherapy. 4. We conclude that periodical urinary thioether determinations should be made available to hospital staff as well as cancer patients to minimize the risks of the cytotoxic drugs.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
