SARS-CoV-2会影响阿尔茨海默病

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-03-07 DOI:10.1038/s41593-025-01918-1

Laura Zelenka

引用次数: 0

摘要

患有急性或严重冠状病毒病2019 （COVID-19）的患者被发现表现出与痴呆症相关的生物标志物。在《自然医学》发表的一项观察性研究中，Duff等人调查了与阿尔茨海默病相关的血浆蛋白质组学生物标志物是否与严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）感染有关。他们发现，在SARS-CoV-2感染后，血浆生物标志物的变化与较高水平的脑β-淀粉样蛋白病理和阿尔茨海默病相关的脑成像特征增加有关。SARS-CoV-2感染对血浆生物标志物的影响在因COVID-19住院或有高血压病史的参与者中更为明显。这项研究的结果表明，轻度至中度SARS-CoV-2感染与大脑β-淀粉样蛋白病理的开始或加速之间存在潜在联系，并暗示在COVID-19大流行之后，阿尔茨海默病的未来发病率可能会增加。原始参考文献：Nat. Med. https://doi.org/10.1038/s41591-024-03426-4（2025）。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.