Sasan Rahmanian, Zahra Salimi, Mohammad Masoumvand, Zohre Aghakhani Nejad, Mohamadtaghi Ghorbani Hesari, Seyed Reza Mirshafaei, Mohammad Keshavarz Mohammadian, Khadijeh Abbasi Mobarakeh, Masoomeh Ataei Kachooei, Ali Shamsi-Goushki, Sara Khoshdooz, Parsa Bahmani, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh
{"title":"膳食摄入维生素A和β -胡萝卜素会增加患高血压的风险吗？","authors":"Sasan Rahmanian, Zahra Salimi, Mohammad Masoumvand, Zohre Aghakhani Nejad, Mohamadtaghi Ghorbani Hesari, Seyed Reza Mirshafaei, Mohammad Keshavarz Mohammadian, Khadijeh Abbasi Mobarakeh, Masoomeh Ataei Kachooei, Ali Shamsi-Goushki, Sara Khoshdooz, Parsa Bahmani, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh","doi":"10.1097/XCE.0000000000000316","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is a major global public health issue influenced by genetics and lifestyle factors such as diet and psychological stress. Previous research suggests a potential link between HTN and dietary vitamin A intake. This study aims to explore the association between HTN and the intake of various forms of vitamin A.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 1239 patients with HTN and 2945 normotensive individuals aged 35-70 years in Sabzevar, Iran. Dietary vitamin A intake was assessed using the Nutritionist IV software and a food frequency questionnaire.</p><p><strong>Result: </strong>A positive association was found between HTN with total vitamin A intake [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.01-1.05, <i>P</i> = 0.04] and β-carotene intake (OR: 1.03, 95% CI: 1.02-1.05, <i>P</i> = 0.03) after adjusting for age and sex. These associations remained statistically significant after adjusting for physical activity and BMI. The association between HTN and β-carotene intake remained significant after additional adjustment for calorie intake. No significant association was observed between dietary retinol intake and HTN.</p><p><strong>Conclusion: </strong>Increased dietary intake of vitamin A and β-carotene may be associated with a higher risk of HTN. Further longitudinal studies are needed to confirm these findings and elucidate the underlying mechanisms.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"13 4","pages":"e00316"},"PeriodicalIF":1.3000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884834/pdf/","citationCount":"0","resultStr":"{\"title\":\"Does dietary intake of vitamin A and beta-carotene increase the risk of hypertension?\",\"authors\":\"Sasan Rahmanian, Zahra Salimi, Mohammad Masoumvand, Zohre Aghakhani Nejad, Mohamadtaghi Ghorbani Hesari, Seyed Reza Mirshafaei, Mohammad Keshavarz Mohammadian, Khadijeh Abbasi Mobarakeh, Masoomeh Ataei Kachooei, Ali Shamsi-Goushki, Sara Khoshdooz, Parsa Bahmani, Saeid Doaei, Akram Kooshki, Maryam Gholamalizadeh\",\"doi\":\"10.1097/XCE.0000000000000316\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Hypertension (HTN) is a major global public health issue influenced by genetics and lifestyle factors such as diet and psychological stress. Previous research suggests a potential link between HTN and dietary vitamin A intake. This study aims to explore the association between HTN and the intake of various forms of vitamin A.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 1239 patients with HTN and 2945 normotensive individuals aged 35-70 years in Sabzevar, Iran. Dietary vitamin A intake was assessed using the Nutritionist IV software and a food frequency questionnaire.</p><p><strong>Result: </strong>A positive association was found between HTN with total vitamin A intake [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.01-1.05, <i>P</i> = 0.04] and β-carotene intake (OR: 1.03, 95% CI: 1.02-1.05, <i>P</i> = 0.03) after adjusting for age and sex. These associations remained statistically significant after adjusting for physical activity and BMI. The association between HTN and β-carotene intake remained significant after additional adjustment for calorie intake. No significant association was observed between dietary retinol intake and HTN.</p><p><strong>Conclusion: </strong>Increased dietary intake of vitamin A and β-carotene may be associated with a higher risk of HTN. 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引用次数: 0
摘要
背景：高血压（HTN）是一个主要的全球公共卫生问题，受遗传和生活方式因素（如饮食和心理压力）的影响。先前的研究表明，HTN与饮食中维生素a的摄入量之间存在潜在的联系。本研究旨在探讨HTN与各种维生素a摄入之间的关系。方法：本横断面研究在伊朗Sabzevar进行，年龄在35-70岁之间的1239例HTN患者和2945例血压正常的个体。使用营养师IV软件和食物频率问卷评估膳食维生素A摄入量。结果：调整年龄和性别后，HTN与总维生素A摄入量[比值比（OR）： 1.03, 95%可信区间（CI）： 1.01-1.05, P = 0.04]和β-胡萝卜素摄入量（OR: 1.03, 95% CI: 1.02-1.05, P = 0.03）呈正相关。在调整体力活动和体重指数后，这些关联仍然具有统计学意义。在额外调整卡路里摄入量后，HTN与β-胡萝卜素摄入量之间的关联仍然显著。饮食中视黄醇摄入量与HTN之间无显著相关性。结论：饮食中维生素A和β-胡萝卜素摄入量的增加可能与HTN的高风险有关。需要进一步的纵向研究来证实这些发现并阐明潜在的机制。
Does dietary intake of vitamin A and beta-carotene increase the risk of hypertension?
Background: Hypertension (HTN) is a major global public health issue influenced by genetics and lifestyle factors such as diet and psychological stress. Previous research suggests a potential link between HTN and dietary vitamin A intake. This study aims to explore the association between HTN and the intake of various forms of vitamin A.
Methods: This cross-sectional study was conducted on 1239 patients with HTN and 2945 normotensive individuals aged 35-70 years in Sabzevar, Iran. Dietary vitamin A intake was assessed using the Nutritionist IV software and a food frequency questionnaire.
Result: A positive association was found between HTN with total vitamin A intake [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.01-1.05, P = 0.04] and β-carotene intake (OR: 1.03, 95% CI: 1.02-1.05, P = 0.03) after adjusting for age and sex. These associations remained statistically significant after adjusting for physical activity and BMI. The association between HTN and β-carotene intake remained significant after additional adjustment for calorie intake. No significant association was observed between dietary retinol intake and HTN.
Conclusion: Increased dietary intake of vitamin A and β-carotene may be associated with a higher risk of HTN. Further longitudinal studies are needed to confirm these findings and elucidate the underlying mechanisms.
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