台湾患有炎症性肠病母亲的妊娠和围产期结局:一项国家数据库分析。

IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Chi-Nien Chen, Hsin-Yun Wu, Meng-Tzu Weng, Chiuan-Bo Huang, Chien-Chih Tung, Shu-Chen Wei, Po-Nien Tsao
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引用次数: 0

摘要

背景:患有炎症性肠病的孕妇经常经历次优的围产期结局。2001年至2003年进行的一项台湾研究显示,患有溃疡性结肠炎的母亲所生的婴儿早产和出生体重低的风险更高。随着疾病管理的进步,我们旨在调查2004年至2018年台湾炎症性肠病母亲的妊娠和围产期结局。方法:我们整合了2004 - 2018年台湾妇幼健康数据库、出生报告数据库、全民医保数据库和大病登记数据库的数据。使用国际疾病分类代码和灾难性疾病登记处确定患有炎症性肠病的母亲,并根据分娩年份和母亲年龄与健康孕妇进行1:10匹配。统计分析包括卡方检验和条件逻辑回归模型。结果:共记录了3,059,647例分娩,其中146例分娩的母亲患有IBD(126例患有溃疡性结肠炎,20例患有克罗恩病)。我们观察到患有炎症性肠病的母亲与对照组在死产、早产、剖宫产、低出生体重、小于或大于胎龄新生儿或Apgar评分方面没有显著差异。妊娠期高血压疾病在炎症性肠病组患病率较低(4.1% vs 13.6%;p = 0.001)。亚组分析显示,溃疡性结肠炎和克罗恩病的结果与社会经济地位和疾病持续时间一致。结论:台湾炎症性肠病妇女的妊娠和围产期结局与健康妇女相似。虽然没有观察到统计学上的显著差异,但某些结果的有限统计能力值得谨慎解释。这些发现强调需要在更大的队列或汇总数据集中进行进一步研究,以探索微小但可能具有临床意义的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pregnancy and perinatal outcomes of mothers with inflammatory bowel disease in Taiwan: A national database analysis.

Background: Pregnant women with inflammatory bowel disease frequently experience suboptimal perinatal outcomes. One Taiwanese study conducted from 2001 to 2003 revealed higher risks of preterm birth and low birth weight in infants born to mothers with ulcerative colitis. With the advancement in disease management, we aim to investigate the pregnancy and perinatal outcomes of Taiwanese mothers with inflammatory bowel disease between 2004 and 2018.

Methods: We integrated data from Taiwan's Maternal and Child Health Database, Birth Reporting Database, National Health Insurance Database, and Catastrophic Illness Registry from 2004 to 2018. Mothers with inflammatory bowel disease were identified using International Classification of Diseases codes and the Catastrophic Illness Registry and matched 1:10 with healthy pregnant women based on the year of childbirth and maternal age. Statistical analyses involved chi-squared tests and conditional logistic regression models.

Results: A total of 3,059,647 births were recorded, of which 146 were born to mothers with IBD (126 to those with ulcerative colitis and 20 to those with Crohn's disease). We observed no significant differences in stillbirths, preterm births, cesarean deliveries, low birth weights, small- or large-for-gestational-age newborns, or Apgar scores between the mothers with inflammatory bowel disease and the controls. Hypertensive disorders of pregnancy were less prevalent in the inflammatory bowel disease group (4.1% vs 13.6%; P = 0.001). Subgroup analysis revealed consistent outcomes in both ulcerative colitis and Crohn's disease, across socioeconomic status, and disease duration.

Conclusions: Pregnancy and perinatal outcomes are comparable in Taiwanese women with inflammatory bowel disease and matched healthy counterparts. While no statistically significant differences were observed, the limited statistical power for certain outcomes warrants cautious interpretation. These findings highlight the need for further investigation in larger cohorts or pooled datasets to explore small but potentially clinically meaningful differences.

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来源期刊
CiteScore
6.50
自引率
6.20%
发文量
381
审稿时长
57 days
期刊介绍: Journal of the Formosan Medical Association (JFMA), published continuously since 1902, is an open access international general medical journal of the Formosan Medical Association based in Taipei, Taiwan. It is indexed in Current Contents/ Clinical Medicine, Medline, ciSearch, CAB Abstracts, Embase, SIIC Data Bases, Research Alert, BIOSIS, Biological Abstracts, Scopus and ScienceDirect. As a general medical journal, research related to clinical practice and research in all fields of medicine and related disciplines are considered for publication. Article types considered include perspectives, reviews, original papers, case reports, brief communications, correspondence and letters to the editor.
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