Dupilumab疗效与俱乐部细胞分泌蛋白变化的关系

IF 5.8 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2025-05-01 DOI:10.1016/j.anai.2025.02.019

Yui Murai MD, Toshiyuki Koya MD, PhD, Hiroki Koda MD, Wakana Uji MD, Moe Tanaka MD, Masahiro Endo MD, Kyoichiro Oshima MD, Takahiro Matsuda MD, Hiroshi Ueno MD, PhD, Ami Aoki MD, PhD, Kenjiro Shima MD, PhD, Yosuke Kimura MD, PhD, Toshiaki Kikuchi MD, PhD

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引用次数: 0

摘要

背景：虽然dupilumab治疗严重哮喘的疗效已被评估，但其作用的详细机制尚不清楚。目的：分析杜匹单抗对血清俱乐部细胞分泌蛋白16 （CC16）的影响。方法：纳入了25例在使用杜匹单抗之前和大约4个月后接受了计算机断层扫描（CT）的患者。比较dupilumab给药前后的临床和CT参数，如粘液堵塞评分和壁面积测量，以及血清CC16水平。研究了临床背景与治疗效果的关系。结果：引入杜匹单抗后，黏液塞数量和气道壁面积明显减少。黏液塞数量与年龄和血清免疫球蛋白E （IgE）水平呈正相关。黏液塞的数量和气道壁面积与预测用力呼气容积（FEV1）和最大呼气中流量（MMEF）的百分比呈负相关。Dupilumab治疗导致血清CC16水平显著升高，哮喘症状、生活质量（QOL）评分、FEV1和加重频率显著改善。此外，CC16的变化与呼出一氧化氮分数、IgE、QOL评分、FEV1、MMEF和粘液堵塞评分的变化显著相关。结论：这些数据表明，dupilumab通过改变气道上皮环境改善症状和呼吸功能。

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Dupilumab efficacy in relation to changes in club cell secretory protein 16

Background

Although the performance of dupilumab in severe asthma has been evaluated, the detailed mechanism underlying its effect remains unclear.

Objective

To analyze the effect of dupilumab on serum club cell secretory protein 16 (CC16).

Methods

A total of 25 patients who were administered dupilumab and underwent computed tomography before and approximately 4 months after the introduction of dupilumab were included. Clinical and computed tomography parameters before and after dupilumab administration, such as mucus plug score and wall area measurement, were compared along with serum CC16 levels. The correlation between the clinical background and treatment effects was also evaluated.

Results

The number of mucus plugs and airway wall area decreased significantly after dupilumab introduction. The number of mucus plugs was positively correlated with both age and serum IgE levels. The number of mucus plugs and airway wall area was inversely correlated with percent of predicted forced expiratory volume in 1 second (FEV₁) and maximal mid-expiratory flow. Dupilumab treatment resulted in a significant increase in serum CC16 levels and led to a significant improvement in asthma symptoms, quality-of-life scores, FEV₁, and exacerbation frequency. In addition, changes in CC16 were significantly correlated with changes in the fraction of exhaled nitric oxide, IgE, quality-of-life score, FEV₁, maximal mid-expiratory flow, and mucus plug score.

Conclusion

These data suggest that dupilumab improves symptoms and respiratory functions by altering the airway epithelial environment.

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.