健康杂交宠物兔(Oryctolagus cuuniculus)和疑似慢性肾脏疾病家兔的尿液化学。

IF 1.3 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Translational Animal Science Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI:10.1093/tas/txaf002
Yeh Sze-Yu, Sung Chi-Hsuan, Liu Pin-Chen, Wu Ching-Fen, Lin Tsai-Lu, Cheng Tsung-Li, Chi-Chung Chou
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引用次数: 0

摘要

用于早期检测肾功能下降的肾脏生物标志物已经在狗和猫中进行了广泛的研究,但对宠物兔的研究有限。具体而言,对杂交家兔尿液指标的研究很少。因此,本研究旨在评估尿液分析在杂交宠物兔中的潜在应用。收集了来自3个诊所的30只健康杂交宠物兔和11只疑似肾脏疾病(KD)兔的尿液样本。建立尿蛋白、肌酐(uCRE)、尿蛋白与肌酐(UPC)比值、γ -谷氨酰转移酶(uGGT)和uGGT比值等泌尿指标的RIs,并与两个已发表的参考区间(RIs)进行比较。结果表明,与一项仅涉及纯种兔子的已发表研究相比,健康兔子的尿蛋白水平始终较低,UPC比率异常。KD家兔尿蛋白水平升高,UPC比值(P P P P)显著升高
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Urinary chemistry in healthy cross-bred pet rabbits (Oryctolagus cuniculus) and rabbits with suspected chronic kidney disease.

Renal biomarkers for early detection of decreased kidney function have been extensively studied in dogs and cats, but there is limited research for pet rabbits. Specifically, studies on urinary indices for cross-bred rabbits are scarce. Therefore, this study aimed to assess the potential use of urinalysis in cross-bred pet rabbits. Urine samples from 30 healthy crossbred pet rabbits and 11 rabbits with suspected kidney disease (KD) from three clinics were collected. RIs of urinary indices, including urinary protein, creatinine (uCRE), urinary protein-to-creatinine (UPC) ratio, gamma-glutamyl transferase (uGGT), and uGGT ratio, were established and compared to two published reference intervals (RIs). The results showed that healthy rabbits consistently had low urine protein levels and abnormal UPC ratios, compared to a published study involving only pure-bred rabbits. Rabbits with KD had higher urine protein levels and a significantly higher UPC ratio (P < 0.001), with 63% having ratios greater than 0.4. Additionally, rabbits with KD showed significantly (P < 0.001) lower uCRE levels and urine specific gravity (USG) with elevated uGGT index (P < 0.05), compared to the healthy group. Significant differences (P < 0.05) were also observed in urine color, turbidity, pH, and positivity of the occult blood by dipstick. This study underscores potential breed-specific variations in urinary protein levels and UPC ratio, as well as highlights the diagnostic potential of USG, UPC ratio, and uGGT index in rabbits with KD. However, the presence of breed-specific variations and technical nuances in laboratory equipment necessitate careful interpretation of results. Therefore, further studies across larger and more diverse rabbit populations are crucial to validate the diagnostic performance of urinary indices in diagnosing KD in rabbits.

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来源期刊
Translational Animal Science
Translational Animal Science Veterinary-Veterinary (all)
CiteScore
2.80
自引率
15.40%
发文量
149
审稿时长
8 weeks
期刊介绍: Translational Animal Science (TAS) is the first open access-open review animal science journal, encompassing a broad scope of research topics in animal science. TAS focuses on translating basic science to innovation, and validation of these innovations by various segments of the allied animal industry. Readers of TAS will typically represent education, industry, and government, including research, teaching, administration, extension, management, quality assurance, product development, and technical services. Those interested in TAS typically include animal breeders, economists, embryologists, engineers, food scientists, geneticists, microbiologists, nutritionists, veterinarians, physiologists, processors, public health professionals, and others with an interest in animal production and applied aspects of animal sciences.
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