Nicholas Contento, David A Paul, G Edward Vates, Brent Johnson, Zachary Brehm, Ismat Shafiq
{"title":"催乳素瘤患者多巴胺激动剂与体重变化。","authors":"Nicholas Contento, David A Paul, G Edward Vates, Brent Johnson, Zachary Brehm, Ismat Shafiq","doi":"10.1007/s11102-025-01510-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Prolactinomas, the predominant pituitary adenoma type, are primarily treated with dopamine agonists to decrease prolactin levels and tumor size. The use of dopamine agonists has been shown to improve metabolic parameters and lead to weight loss in prolactinoma patients. However, the data is conflicting and sparse. In the current study, we aim to review weight variations in prolactinoma patients treated with dopamine agonists.</p><p><strong>Methods: </strong>We identified prolactinoma patients referred to one pituitary clinic between 2010 and 2020. Data from prolactinoma patients treated with dopamine agonist therapy were retrospectively collected over the span of 1 year. Serum prolactin and weight measurements were obtained at the time of diagnosis and at 3-months, 6-months, and 12-month time points. We also collected information on the patient's age, sex, BMI, diabetes history, and dopamine agonist treatment regimen.</p><p><strong>Results: </strong>91 patients with prolactinoma treated with dopamine agonist were included in the study. Among the 91 patients, 47 were females and 44 were males. The average age for females was 30.5 years and for males were 49 years. The average BMI in females was 31.02 kg/m<sup>2</sup> and in men were 31.05 kg/m<sup>2</sup>. The prolactin level at baseline was higher in men with an average of 779.95 ng/ml while in females' initial prolactin levels were 433 ng/ml. Prolactin levels decreased to normal levels as dopamine agonist treatment was continued over the course of one year, with the most precipitous drop occurring between 0 and 3 months. While prolactin levels at baseline were higher in men, prolactin levels in men dropped on average 644 ng/mL over the 0-3-month period, compared to the 257 ng/mL average drop in women. While not significant, patients overall lost weight over the treatment period, with men losing on average 7.8 pounds and women losing 1.1 pound.</p><p><strong>Conclusions: </strong>The use of dopamine agonists for a duration of about 12 months did not result in statistically significant weight loss among patients with prolactinoma.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"28 2","pages":"35"},"PeriodicalIF":3.3000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dopamine agonists and weight changes in prolactinoma patients.\",\"authors\":\"Nicholas Contento, David A Paul, G Edward Vates, Brent Johnson, Zachary Brehm, Ismat Shafiq\",\"doi\":\"10.1007/s11102-025-01510-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Prolactinomas, the predominant pituitary adenoma type, are primarily treated with dopamine agonists to decrease prolactin levels and tumor size. The use of dopamine agonists has been shown to improve metabolic parameters and lead to weight loss in prolactinoma patients. However, the data is conflicting and sparse. In the current study, we aim to review weight variations in prolactinoma patients treated with dopamine agonists.</p><p><strong>Methods: </strong>We identified prolactinoma patients referred to one pituitary clinic between 2010 and 2020. Data from prolactinoma patients treated with dopamine agonist therapy were retrospectively collected over the span of 1 year. Serum prolactin and weight measurements were obtained at the time of diagnosis and at 3-months, 6-months, and 12-month time points. We also collected information on the patient's age, sex, BMI, diabetes history, and dopamine agonist treatment regimen.</p><p><strong>Results: </strong>91 patients with prolactinoma treated with dopamine agonist were included in the study. Among the 91 patients, 47 were females and 44 were males. The average age for females was 30.5 years and for males were 49 years. The average BMI in females was 31.02 kg/m<sup>2</sup> and in men were 31.05 kg/m<sup>2</sup>. The prolactin level at baseline was higher in men with an average of 779.95 ng/ml while in females' initial prolactin levels were 433 ng/ml. Prolactin levels decreased to normal levels as dopamine agonist treatment was continued over the course of one year, with the most precipitous drop occurring between 0 and 3 months. While prolactin levels at baseline were higher in men, prolactin levels in men dropped on average 644 ng/mL over the 0-3-month period, compared to the 257 ng/mL average drop in women. While not significant, patients overall lost weight over the treatment period, with men losing on average 7.8 pounds and women losing 1.1 pound.</p><p><strong>Conclusions: </strong>The use of dopamine agonists for a duration of about 12 months did not result in statistically significant weight loss among patients with prolactinoma.</p>\",\"PeriodicalId\":20202,\"journal\":{\"name\":\"Pituitary\",\"volume\":\"28 2\",\"pages\":\"35\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pituitary\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11102-025-01510-7\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pituitary","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11102-025-01510-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Dopamine agonists and weight changes in prolactinoma patients.
Purpose: Prolactinomas, the predominant pituitary adenoma type, are primarily treated with dopamine agonists to decrease prolactin levels and tumor size. The use of dopamine agonists has been shown to improve metabolic parameters and lead to weight loss in prolactinoma patients. However, the data is conflicting and sparse. In the current study, we aim to review weight variations in prolactinoma patients treated with dopamine agonists.
Methods: We identified prolactinoma patients referred to one pituitary clinic between 2010 and 2020. Data from prolactinoma patients treated with dopamine agonist therapy were retrospectively collected over the span of 1 year. Serum prolactin and weight measurements were obtained at the time of diagnosis and at 3-months, 6-months, and 12-month time points. We also collected information on the patient's age, sex, BMI, diabetes history, and dopamine agonist treatment regimen.
Results: 91 patients with prolactinoma treated with dopamine agonist were included in the study. Among the 91 patients, 47 were females and 44 were males. The average age for females was 30.5 years and for males were 49 years. The average BMI in females was 31.02 kg/m2 and in men were 31.05 kg/m2. The prolactin level at baseline was higher in men with an average of 779.95 ng/ml while in females' initial prolactin levels were 433 ng/ml. Prolactin levels decreased to normal levels as dopamine agonist treatment was continued over the course of one year, with the most precipitous drop occurring between 0 and 3 months. While prolactin levels at baseline were higher in men, prolactin levels in men dropped on average 644 ng/mL over the 0-3-month period, compared to the 257 ng/mL average drop in women. While not significant, patients overall lost weight over the treatment period, with men losing on average 7.8 pounds and women losing 1.1 pound.
Conclusions: The use of dopamine agonists for a duration of about 12 months did not result in statistically significant weight loss among patients with prolactinoma.
期刊介绍：
Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease.
The journal considers:
Biology of Pituitary Tumors
Mechanisms of Pituitary Hormone Secretion
Regulation of Pituitary Function
Prospective Clinical Studies of Pituitary Disease
Critical Basic and Clinical Reviews
Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.
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