基因组动力学、基因表达和发育中的r环稳态

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-03-04 DOI:10.1016/j.gde.2025.102325

Paula Aguilera , Andrés Aguilera

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引用次数: 0

摘要

r环是一把双刃剑，其功能作用在许多情况下对基因组完整性和基因表达构成威胁，并在细胞生理和发育中产生相关后果。许多因素通过在R-loop预防、解决或修复R-loop诱导的DNA损伤的水平上起作用来控制R-loop稳态。破译在不同压力下产生的r环的作用以及控制其稳态的过多过程对于评估其在细胞生理学中的影响及其与发育和疾病相关的生物学意义至关重要。在这里，我们回顾了过去两年的出版物，以帮助理解它们的生物学作用。

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R-loop homeostasis in genome dynamics, gene expression and development

R-loops are double-edge swords with functional roles that in many cases constitute a threat to genome integrity and gene expression with relevant consequences in cell physiology and development. A number of factors have evolved to control R-loop homeostasis by acting at the levels of R-loop prevention, resolution, or the repair of the R-loop-induced DNA lesion. Deciphering the role of R-loops generated under different stresses and the plethora of processes controlling their homeostasis has become crucial to evaluate their impact in cell physiology and the biological significance of their association with development and disease. Here, we review publications of the last 2 years that help understand their biological role.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)